Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome
about
Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein VKey role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flowPlatelets mediate cytotoxic T lymphocyte-induced liver damage.Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 geneThe contribution of mouse models to the understanding of constitutional thrombocytopeniaDetachment of surface membrane invagination systems by cationic amphiphilic drugsA novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and functionA PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1Serum response factor is an essential transcription factor in megakaryocytic maturationADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis.Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammationGenetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis.In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation.Hemostatic and hematological abnormalities in gain-of-function fps/fes transgenic mice are associated with the angiogenic phenotype.Qualitative disorders of platelets and megakaryocytes.The biogenesis of platelets from megakaryocyte proplatelets.A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.Targeting von Willebrand factor and platelet glycoprotein Ib receptor.FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies.Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy.New insights into the versatile roles of platelet FlnA.Does size matter in platelet production?Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality.Non-myeloablative conditioning with busulfan before hematopoietic stem cell transplantation leads to phenotypic correction of murine Bernard-Soulier syndrome.Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond.A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation.Special considerations in the evaluation of the hematology and hemostasis of mutant mice.The organizing principle of the platelet glycoprotein Ib-IX-V complex.Platelets as delivery systems for disease treatmentsAbnormal whole blood thrombi in humans with inherited platelet receptor defects.Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume.Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defectsThe birth of the platelet.
P2860
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P2860
Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome
description
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2000
@ast
im März 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/03/14)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/03/14)
@nl
наукова стаття, опублікована в березні 2000
@uk
name
Generation and rescue of a mur ...... : the Bernard-Soulier syndrome
@ast
Generation and rescue of a mur ...... : the Bernard-Soulier syndrome
@en
Generation and rescue of a mur ...... : the Bernard-Soulier syndrome
@nl
type
label
Generation and rescue of a mur ...... : the Bernard-Soulier syndrome
@ast
Generation and rescue of a mur ...... : the Bernard-Soulier syndrome
@en
Generation and rescue of a mur ...... : the Bernard-Soulier syndrome
@nl
prefLabel
Generation and rescue of a mur ...... : the Bernard-Soulier syndrome
@ast
Generation and rescue of a mur ...... : the Bernard-Soulier syndrome
@en
Generation and rescue of a mur ...... : the Bernard-Soulier syndrome
@nl
P2093
P2860
P3181
P356
P1476
Generation and rescue of a mur ...... : the Bernard-Soulier syndrome
@en
P2093
S. Russell
Z. M. Ruggeri
P2860
P304
P3181
P356
10.1073/PNAS.050582097
P407
P577
2000-03-14T00:00:00Z