Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
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Sorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cellsGene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypesMAPK pathway activation in pilocytic astrocytomaThe neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 miceOncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosisOptimizing biologically targeted clinical trials for neurofibromatosis.Pediatric low-grade gliomas and the need for new options for therapy: Why and how?Comprehensive pharmacological profiling of neurofibromatosis cell lines.Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival.Defective cAMP generation underlies the sensitivity of CNS neurons to neurofibromatosis-1 heterozygosity.Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner.Neurofibromatosis type 1: modeling CNS dysfunction.An 80-year experience with optic nerve glioma cases at the Armed Forces Institute of Pathology: evolution from museum to molecular evaluation suggests possibe interventions in the cellular senescence and microglial pathways (an American OphthalmologNovel recurrently mutated genes and a prognostic mutation signature in colorectal cancer.Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating gliomaBRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.Partial Blindness to Submicron Topography in NF1 Haploinsufficient Cultured Fibroblasts Indicates a New Function of Neurofibromin in Regulation of Mechanosensoric.Pediatric gliomas as neurodevelopmental disordersTreatment of pediatric brain tumors.Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.Using neurofibromatosis-1 to better understand and treat pediatric low-grade gliomaNeurofibromin regulates somatic growth through the hypothalamic-pituitary axisHow does the Schwann cell lineage form tumors in NF1?NF1 germline mutation differentially dictates optic glioma formation and growth in neurofibromatosis-1.PTEN dosage is essential for neurofibroma development and malignant transformationSuppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity.Targeting Ras-RAF-ERK and its interactive pathways as a novel therapy for malignant gliomas.Targeting group I p21-activated kinases to control malignant peripheral nerve sheath tumor growth and metastasis.LncRNA TSLC1-AS1 is a novel tumor suppressor in glioma.The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo.Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature.The neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent mannerOptic Pathway Gliomas in Neurofibromatosis Type 1.Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma.Restoring functional neurofibromin by protein transduction.Graph complexity analysis identifies an ETV5 tumor-specific network in human and murine low-grade glioma.
P2860
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P2860
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
description
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artikull shkencor
@sq
artículu científicu espublizáu en 2005
@ast
im Januar 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 2005
@uk
مقالة علمية (نشرت عام 2005)
@ar
name
Glioma formation in neurofibro ...... ivation of K-RAS in astrocytes
@ast
Glioma formation in neurofibro ...... ivation of K-RAS in astrocytes
@en
Glioma formation in neurofibro ...... ivation of K-RAS in astrocytes
@nl
type
label
Glioma formation in neurofibro ...... ivation of K-RAS in astrocytes
@ast
Glioma formation in neurofibro ...... ivation of K-RAS in astrocytes
@en
Glioma formation in neurofibro ...... ivation of K-RAS in astrocytes
@nl
prefLabel
Glioma formation in neurofibro ...... ivation of K-RAS in astrocytes
@ast
Glioma formation in neurofibro ...... ivation of K-RAS in astrocytes
@en
Glioma formation in neurofibro ...... ivation of K-RAS in astrocytes
@nl
P2093
P921
P1433
P1476
Glioma formation in neurofibro ...... ivation of K-RAS in astrocytes
@en
P2093
Arie Perry
Biplab Dasgupta
David H. Gutmann
P304
P407
P577
2005-01-01T00:00:00Z