Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells
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Sustaining rapid vesicular release at active zones: potential roles for vesicle tetheringFerlins: regulators of vesicle fusion for auditory neurotransmission, receptor trafficking and membrane repairNew insights into cochlear sound encodingDecreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorderOtoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cellsMice lacking the cerebral cortex develop normal song: insights into the foundations of vocal learningMice do not require auditory input for the normal development of their ultrasonic vocalizations.Perinatal thiamine deficiency causes cochlear innervation abnormalities in mice.Cochlear hair cells: The sound-sensing machines.Identification of a novel pathogenic OTOF variant causative of nonsyndromic hearing loss with high frequency in the Ashkenazi Jewish population.Synaptic transmission between end bulbs of Held and bushy cells in the cochlear nucleus of mice with a mutation in Otoferlin.Otoferlin deficiency in zebrafish results in defects in balance and hearing: rescue of the balance and hearing phenotype with full-length and truncated forms of mouse otoferlin.Relating structure and function of inner hair cell ribbon synapses.A simple method for purification of vestibular hair cells and non-sensory cells, and application for proteomic analysis.Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis.Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy.Modeling the influence of short term depression in vesicle release and stochastic calcium channel gating on auditory nerve spontaneous firing statistics.The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative geneDevelopmental acquisition of a rapid calcium-regulated vesicle supply allows sustained high rates of exocytosis in auditory hair cells.Loudness adaptation accompanying ribbon synapse and auditory nerve disorders.Optogenetic stimulation of the auditory pathway.Modes and regulation of endocytic membrane retrieval in mouse auditory hair cellsTransmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies.Functional assembly of mammalian cochlear hair cellsCalcium signaling in the cochlea - Molecular mechanisms and physiopathological implications.Information from cochlear potentials and genetic mutations helps localize the lesion site in auditory neuropathy.Short-term facilitation modulates size and timing of the synaptic response at the inner hair cell ribbon synapse.Recovery from short-term depression and facilitation is ultrafast and Ca2+ dependent at auditory hair cell synapses.Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis.The diverse roles of ribbon synapses in sensory neurotransmission.Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activityCholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses.Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis.EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cellsA new probe for super-resolution imaging of membranes elucidates trafficking pathwaysInsights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptomeCharacterization of the lipid binding properties of Otoferlin reveals specific interactions between PI(4,5)P2 and the C2C and C2F domains.Sharp Ca²⁺ nanodomains beneath the ribbon promote highly synchronous multivesicular release at hair cell synapses.The SNARE complex in neuronal and sensory cells.
P2860
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P2860
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells
description
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im Juli 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/07/01)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/07/01)
@nl
наукова стаття, опублікована в липні 2010
@uk
مقالة علمية (نشرت في يوليو 2010)
@ar
name
Hearing requires otoferlin-dep ...... ynaptic vesicles in hair cells
@ast
Hearing requires otoferlin-dep ...... ynaptic vesicles in hair cells
@en
Hearing requires otoferlin-dep ...... ynaptic vesicles in hair cells
@nl
type
label
Hearing requires otoferlin-dep ...... ynaptic vesicles in hair cells
@ast
Hearing requires otoferlin-dep ...... ynaptic vesicles in hair cells
@en
Hearing requires otoferlin-dep ...... ynaptic vesicles in hair cells
@nl
prefLabel
Hearing requires otoferlin-dep ...... ynaptic vesicles in hair cells
@ast
Hearing requires otoferlin-dep ...... ynaptic vesicles in hair cells
@en
Hearing requires otoferlin-dep ...... ynaptic vesicles in hair cells
@nl
P2093
P50
P3181
P356
P1433
P1476
Hearing requires otoferlin-dep ...... ynaptic vesicles in hair cells
@en
P2093
Dietmar Riedel
Janice S. Bailey
Kirsten Reuter
Lisa M. Tarantino
Livia Lasarow
Martin Schwander
Nicola Strenzke
Tina Pangrsic
Ulrich Müller
P2888
P304
P3181
P356
10.1038/NN.2578
P407
P577
2010-07-01T00:00:00Z