Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
about
Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degenerationHUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transportSyntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide productionSyntabulin-mediated anterograde transport of mitochondria along neuronal processesTransporting mitochondria in neuronsGenes associated with Alzheimer's disease: an overview and current statusAlterations in Mitochondrial Quality Control in Alzheimer's DiseaseMitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic interventionGenetic heterogeneity in Alzheimer disease and implications for treatment strategiesDefects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's diseaseAmyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal NeuronsNebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signalingHDAC6 regulates mitochondrial transport in hippocampal neuronsDisruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid betaCoordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neuronsSmall molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophyAxonal transport and neurodegenerative disease: can we see the elephant?Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein.Force-velocity curves of motor proteins cooperating in vivo.Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration.Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.β-Amyloid impairs axonal BDNF retrograde trafficking.Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivoDendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer-treated hippocampal neuronsAlzheimer's disease and the fornix.The genetics of axonal transport and axonal transport disordersImpairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease.Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice.Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation.Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease.Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease participants.prickle modulates microtubule polarity and axonal transport to ameliorate seizures in flies.Alzheimer's disease: diverse aspects of mitochondrial malfunctioning.DTI analyses and clinical applications in Alzheimer's disease.Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function.Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.
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P2860
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
description
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Juni 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/06/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/06/01)
@nl
наукова стаття, опублікована в червні 2003
@uk
مقالة علمية (نشرت في يونيو 2003)
@ar
name
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
@ast
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
@en
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
@nl
type
label
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
@ast
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
@en
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
@nl
prefLabel
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
@ast
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
@en
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
@nl
P2093
P921
P3181
P1476
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
@en
P2093
Alejandra Pelsman
Gerardo Morfini
Gustavo Pigino
Jorge Busciglio
Mark P Mattson
Scott T Brady
P304
P3181
P356
10.1523/JNEUROSCI.23-11-04499.2003
P407
P577
2003-06-01T00:00:00Z