The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs
about
Translational research in nicotine dependenceGenetic matters: thirty years of progress using mouse models in nicotinic research.nAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives.Natural genetic variability of the neuronal nicotinic acetylcholine receptor subunit genes in mice: Consequences and confoundsThe smoking cessation drug varenicline improves deficient P20-N40 inhibition in DBA/2 mice.Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction.Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity.Variants in nicotinic receptors and risk for nicotine dependence.Pentameric concatenated (alpha4)(2)(beta2)(3) and (alpha4)(3)(beta2)(2) nicotinic acetylcholine receptors: subunit arrangement determines functional expression.Non-agonist-binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the alpha4beta2 nicotinic receptor: an alpha4-alpha4 interface is required for Zn2+ potentiation.Engineering α4β2 nAChRs with reduced or increased nicotine sensitivity via selective disruption of consensus sites in the M3-M4 cytoplasmic loop of the α4 subunit.
P2860
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P2860
The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs
description
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im September 2003 veröffentlicher wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/09/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/09/01)
@nl
наукова стаття, опублікована у вересні 2003
@uk
مقالة علمية (نشرت في سبتمبر 2003)
@ar
name
The mouse Chrna4 A529T polymor ...... affinity alpha 4 beta 2 nAChRs
@ast
The mouse Chrna4 A529T polymor ...... affinity alpha 4 beta 2 nAChRs
@en
The mouse Chrna4 A529T polymor ...... affinity alpha 4 beta 2 nAChRs
@nl
type
label
The mouse Chrna4 A529T polymor ...... affinity alpha 4 beta 2 nAChRs
@ast
The mouse Chrna4 A529T polymor ...... affinity alpha 4 beta 2 nAChRs
@en
The mouse Chrna4 A529T polymor ...... affinity alpha 4 beta 2 nAChRs
@nl
prefLabel
The mouse Chrna4 A529T polymor ...... affinity alpha 4 beta 2 nAChRs
@ast
The mouse Chrna4 A529T polymor ...... affinity alpha 4 beta 2 nAChRs
@en
The mouse Chrna4 A529T polymor ...... affinity alpha 4 beta 2 nAChRs
@nl
P2093
P1433
P1476
The mouse Chrna4 A529T polymor ...... affinity alpha 4 beta 2 nAChRs
@en
P2093
Brody A. Flanagin
Heejeong Kim
Jerry A. Stitzel
Robert L. Macdonald
P304
P577
2003-09-01T00:00:00Z