A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests
about
Epigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug ResponseLight-controlled modulation of gene expression by chemical optoepigenetic probesBifunctional Conjugates with Potent Inhibitory Activity Towards Cyclooxygenase and Histone DeacetylaseSIRT2 is involved in the modulation of depressive behaviors.In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs.Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia.Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat.Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.Kinetic Analysis and Quantification of [¹¹C]Martinostat for in Vivo HDAC Imaging of the Brain.Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance.The Epigenetic Mechanisms of Amphetamine.Insights into neuroepigenetics through human histone deacetylase PET imaging.Histone Posttranslational Modifications in Schizophrenia.Neuroplasticity underlying the comorbidity of pain and depressionIdentification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cellsEpigenetic landscape of amphetamine and methamphetamine addiction in rodents.Genome-Wide Analysis Reveals Selective Modulation of microRNAs and mRNAs by Histone Deacetylase Inhibitor in B Cells Induced to Undergo Class-Switch DNA Recombination and Plasma Cell Differentiation.Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brainBehavioral and omics analyses study on potential involvement of dipeptide balenine through supplementation in diet of senescence-accelerated mouse prone 8.Maternal immune activation epigenetically regulates hippocampal serotonin transporter levels.Epigenetic approaches for bipolar disorder drug discovery.Epigenetic drug discovery for Alzheimer's disease.Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.Genomics and epigenomics in novel schizophrenia drug discovery: translating animal models to clinical research and back.Drugs under early investigation for the treatment of bipolar disorder.Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.Emerging approaches for histone deacetylase inhibitor drug discovery.An update on the epigenetics of psychotic diseases and autism.Epigenetics and addiction.Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL.Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy.HDACs and HDAC Inhibitors in Cancer Development and Therapy.HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models.Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6.Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors.Epigenetic mechanisms of major depression: Targeting neuronal plasticity.Inositol depletion, GSK3 inhibition and bipolar disorder.A longitudinal study of the association between the GNB3 C825T polymorphism and metabolic disturbance in bipolar II patients treated with valproate.
P2860
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P2860
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests
description
2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
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2013年論文
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2013年论文
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name
A selective HDAC 1/2 inhibitor ...... vior in two mood-related tests
@ast
A selective HDAC 1/2 inhibitor ...... vior in two mood-related tests
@en
A selective HDAC 1/2 inhibitor ...... vior in two mood-related tests
@nl
type
label
A selective HDAC 1/2 inhibitor ...... vior in two mood-related tests
@ast
A selective HDAC 1/2 inhibitor ...... vior in two mood-related tests
@en
A selective HDAC 1/2 inhibitor ...... vior in two mood-related tests
@nl
prefLabel
A selective HDAC 1/2 inhibitor ...... vior in two mood-related tests
@ast
A selective HDAC 1/2 inhibitor ...... vior in two mood-related tests
@en
A selective HDAC 1/2 inhibitor ...... vior in two mood-related tests
@nl
P2093
P2860
P50
P3181
P1433
P1476
A selective HDAC 1/2 inhibitor ...... vior in two mood-related tests
@en
P2093
Daniel M Fass
Douglas D Barker
Edward B Holson
Elizabeth L Clore
Erin Berry-Scott
Florence F Wagner
Frederick A Schroeder
Jennifer Gale
Krista M Hennig
Michael C Lewis
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0071323
P407
P577
2013-01-01T00:00:00Z