Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis
about
Elucidation of salicylate attachment in celesticetin biosynthesis opens the door to create a library of more efficient hybrid lincosamide antibioticsLincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism.New Concept of the Biosynthesis of 4-Alkyl-L-Proline Precursors of Lincomycin, Hormaomycin, and Pyrrolobenzodiazepines: Could a γ-Glutamyltransferase Cleave the C-C Bond?Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis.Deacetylation of mycothiol-derived 'waste product' triggers the last biosynthetic steps of lincosamide antibiotics.Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A.Sequence analysis of porothramycin biosynthetic gene cluster.Characterization of Enzymes Catalyzing Transformations of Cysteine S-Conjugated Intermediates in the Lincosamide Biosynthetic Pathway.Evolution-guided adaptation of an adenylation domain substrate specificity to an unusual amino acid.Elusive source of sulfur unravelled
P2860
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P2860
Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis
description
2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
Adaptation of an L-proline ade ...... on of lincosamide biosynthesis
@ast
Adaptation of an L-proline ade ...... on of lincosamide biosynthesis
@en
Adaptation of an L-proline ade ...... on of lincosamide biosynthesis
@nl
type
label
Adaptation of an L-proline ade ...... on of lincosamide biosynthesis
@ast
Adaptation of an L-proline ade ...... on of lincosamide biosynthesis
@en
Adaptation of an L-proline ade ...... on of lincosamide biosynthesis
@nl
prefLabel
Adaptation of an L-proline ade ...... on of lincosamide biosynthesis
@ast
Adaptation of an L-proline ade ...... on of lincosamide biosynthesis
@en
Adaptation of an L-proline ade ...... on of lincosamide biosynthesis
@nl
P2093
P2860
P50
P1433
P1476
Adaptation of an L-proline ade ...... on of lincosamide biosynthesis
@en
P2093
Dana Ulanová
Dominika Chalupská
Eva Kutejová
Markéta Koběrská
Radek Gažák
Tomáš Kučera
P2860
P304
P356
10.1371/JOURNAL.PONE.0084902
P407
P577
2013-12-27T00:00:00Z