PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival
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Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progressionCDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytesAdenosine A(1) receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitroActivation of the p53-p21(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytesPleiotropic effects of PI-3' kinase/Akt signaling in human hepatoma cell proliferation and drug-induced apoptosis.Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction.Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways.Tangeretin and its metabolite 4'-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6KAmino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle.CXC chemokine signaling in the liver: impact on repair and regeneration.Regeneration in pig livers by compensatory hyperplasia induces high levels of telomerase activity.Epidermal growth factor-induced vacuolar (H+)-atpase assembly: a role in signaling via mTORC1 activation.The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control.The role of AEG-1 in the development of liver cancer.Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantationAlteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.Enhanced clonogenic survival induced by protein tyrosine phosphatase (PTP) inhibition after Cr(VI) exposure is mediated by c-Raf and Ras activity.Biological signalling activity measurements using mass spectrometry.Regulatory mechanisms of injury and repair after hepatic ischemia/reperfusionHeterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration.MEK/ERK-dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells.Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells.Role of EGF receptor transactivation in phosphoinositide 3-kinase-dependent activation of MAP kinase by GPCRs.Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling.Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway.Rapamycin ameliorates inflammation and fibrosis in the early phase of cirrhotic portal hypertension in rats through inhibition of mTORC1 but not mTORC2.Cultured rat hepatocytes upregulate Akt and ERK in an ErbB-2-dependent manner.The effect of sorafenib on liver regeneration and angiogenesis after partial hepatectomy in rats.Regulation of signal transduction and role of platelets in liver regenerationProtective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling.Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth.Novel role for amphiregulin in protection from liver injury.Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice.Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways.Chronic hypoxia-induced alterations of key enzymes of glucose oxidative metabolism in developing mouse liver are mTOR dependent.Insulin-Like Growth Factor (IGF) System in Liver Diseases.Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice.Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration.
P2860
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P2860
PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival
description
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im November 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/11/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/11/01)
@nl
наукова стаття, опублікована в листопаді 2002
@uk
مقالة علمية (نشرت في نوفمبر 2002)
@ar
name
PI3K-FRAP/mTOR pathway is crit ...... oth proliferation and survival
@ast
PI3K-FRAP/mTOR pathway is crit ...... oth proliferation and survival
@en
PI3K-FRAP/mTOR pathway is crit ...... oth proliferation and survival
@nl
type
label
PI3K-FRAP/mTOR pathway is crit ...... oth proliferation and survival
@ast
PI3K-FRAP/mTOR pathway is crit ...... oth proliferation and survival
@en
PI3K-FRAP/mTOR pathway is crit ...... oth proliferation and survival
@nl
prefLabel
PI3K-FRAP/mTOR pathway is crit ...... oth proliferation and survival
@ast
PI3K-FRAP/mTOR pathway is crit ...... oth proliferation and survival
@en
PI3K-FRAP/mTOR pathway is crit ...... oth proliferation and survival
@nl
P2093
P356
P1433
P1476
PI3K-FRAP/mTOR pathway is crit ...... oth proliferation and survival
@en
P2093
Alexandre Coutant
Christiane Guguen-Guillouzo
Claude Rescan
David Gilot
Georges Baffet
Pascal Loyer
P304
P356
10.1053/JHEP.2002.36160
P407
P577
2002-11-01T00:00:00Z