Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
about
Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomesCD47 regulates bone mass and tumor metastasis to boneInvolvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humansUnsatisfactory gene transfer into bone-resorbing osteoclasts with liposomal transfection systemsMultiple Roles of the Small GTPase Rab7Modulation of osteoclast differentiation and bone resorption by Rho GTPasesRegulation of osteoclasts by membrane-derived lipid mediatorsFunctions and regulation of circular dorsal rufflesTctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorptionV-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorptionSynaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretionPossible role of direct Rac1-Rab7 interaction in ruffled border formation of osteoclastsLIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption.Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts.Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression.The Roles of Small GTPases in Osteoclast BiologyImpaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function.Intracellular membrane trafficking in bone resorbing osteoclasts.A genetic predictive model for canine hip dysplasia: integration of Genome Wide Association Study (GWAS) and candidate gene approaches.Autophagy proteins regulate the secretory component of osteoclastic bone resorption.Mutation in Osteoactivin Promotes Receptor Activator of NFκB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast FunctionDisruption of CXCR4 enhances osteoclastogenesis and tumor growth in boneThe collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption.Rab13 is upregulated during osteoclast differentiation and associates with small vesicles revealing polarized distribution in resorbing cells.Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclastsRelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice.Rab7 silencing prevents μ-opioid receptor lysosomal targeting and rescues opioid responsiveness to strengthen diabetic neuropathic pain therapy.Membrane trafficking in osteoblasts and osteoclasts: new avenues for understanding and treating skeletal diseasesSteap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation.PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption.Regulation of lysosome biogenesis and functions in osteoclasts.Role and mechanism of action of leucine-rich repeat kinase 1 in bone.Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts.The regulation of osteoclast function and bone resorption by small GTPasesPhospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinaseCytoplasmic terminus of vacuolar type proton pump accessory subunit Ac45 is required for proper interaction with V(0) domain subunits and efficient osteoclastic bone resorption.
P2860
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P2860
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
description
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im Oktober 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/10/19)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/10/19)
@nl
наукова стаття, опублікована в жовтні 2001
@uk
name
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
@ast
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
@en
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
@nl
type
label
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
@ast
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
@en
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
@nl
prefLabel
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
@ast
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
@en
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
@nl
P2093
P2860
P3181
P356
P1476
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
@en
P2093
H. K. Väänänen
T. Laitala-Leinonen
V. Parikka
P2860
P304
39295–39302
P3181
P356
10.1074/JBC.M010999200
P407
P577
2001-10-19T00:00:00Z