Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
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Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partnerEffects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stabilityNovel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1Molecular physiology of mammalian glucokinaseDynamic localization of glucokinase and its regulatory protein in hypothalamic tanycytesMolecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinaseStarvation promotes nuclear accumulation of the hsp70 Ssa4p in yeast cells.A novel glucokinase regulator in pancreatic beta cells: precursor of propionyl-CoA carboxylase beta subunit interacts with glucokinase and augments its activityFunctional characterization of MODY2 mutations highlights the importance of the fine-tuning of glucokinase and its role in glucose sensingDefect in glucokinase translocation in Zucker diabetic fatty ratsCharacterization of glucokinase regulatory protein-deficient miceEvolution of hepatic glucose metabolism: liver-specific glucokinase deficiency explained by parallel loss of the gene for glucokinase regulatory protein (GCKR)Human genetics as a model for target validation: finding new therapies for diabetes.Treatment of diabetes and long-term survival after insulin and glucokinase gene therapy.FHY1 mediates nuclear import of the light-activated phytochrome A photoreceptorMechanisms and signals for the nuclear import of proteinsGlucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity.Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans.Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescenceCellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?Novel polymorphisms in the GCKR gene and their influence on glucose and insulin levels in a Danish twin population.Alternative Use of DNA Binding Domains by the Neurospora White Collar Complex Dictates Circadian Regulation and Light Responses.Discovery of a novel site regulating glucokinase activity following characterization of a new mutation causing hyperinsulinemic hypoglycemia in humansCloning and characterization of feline islet glucokinase.Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivoRole of glucokinase in the subcellular localization of glucokinase regulatory protein.Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes.The n-3 long-chain PUFAs modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents.Extent of pre-translational regulation for the control of nucleocytoplasmic protein localization.GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation.Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity.SUMOylation of pancreatic glucokinase regulates its cellular stability and activityInsights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease.Normal glucose metabolism in carnivores overlaps with diabetes pathology in non-carnivores.Liver glucokinase: An overview on the regulatory mechanisms of its activity.Molecular targeting of the GK-GKRP pathway in diabetes.The role of tanycytes in hypothalamic glucosensing.Antidiabetic Disruptors of the Glucokinase-Glucokinase Regulatory Protein Complex Reorganize a Coulombic Interface.Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein.
P2860
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P2860
Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
description
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im Dezember 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/12/24)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/12/24)
@nl
наукова стаття, опублікована в грудні 1999
@uk
name
Nuclear import of hepatic gluc ...... signal sequence in glucokinase
@ast
Nuclear import of hepatic gluc ...... signal sequence in glucokinase
@en
Nuclear import of hepatic gluc ...... signal sequence in glucokinase
@nl
type
label
Nuclear import of hepatic gluc ...... signal sequence in glucokinase
@ast
Nuclear import of hepatic gluc ...... signal sequence in glucokinase
@en
Nuclear import of hepatic gluc ...... signal sequence in glucokinase
@nl
prefLabel
Nuclear import of hepatic gluc ...... signal sequence in glucokinase
@ast
Nuclear import of hepatic gluc ...... signal sequence in glucokinase
@en
Nuclear import of hepatic gluc ...... signal sequence in glucokinase
@nl
P2093
P2860
P3181
P356
P1476
Nuclear import of hepatic gluc ...... signal sequence in glucokinase
@en
P2093
J. F. Grippo
J. Grimsby
M. A. Magnuson
P2860
P304
37125–37130
P3181
P356
10.1074/JBC.274.52.37125
P407
P577
1999-12-24T00:00:00Z