Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells
about
CHK2 kinase in the DNA damage response and beyondRas and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation.Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent mannerCell death at the intestinal epithelial front line.Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cellsAnoikis of colon carcinoma cells triggered by β-catenin loss can be enhanced by tumor necrosis factor receptor 1 antagonists.Mek activity is required for ErbB2 expression in breast cancer cells detached from the extracellular matrix.Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.ErbB2-dependent downregulation of a pro-apoptotic protein Perp is required for oncogenic transformation of breast epithelial cells.
P2860
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P2860
Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells
description
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2012
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im Juli 2012 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2012/07/15)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd op 2012/07/15)
@nl
наукова стаття, опублікована в липні 2012
@uk
مقالة علمية (نشرت في 15-7-2012)
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name
Tumor suppressor protein kinas ...... of intestinal epithelial cells
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Tumor suppressor protein kinas ...... of intestinal epithelial cells
@en
Tumor suppressor protein kinas ...... of intestinal epithelial cells
@nl
type
label
Tumor suppressor protein kinas ...... of intestinal epithelial cells
@ast
Tumor suppressor protein kinas ...... of intestinal epithelial cells
@en
Tumor suppressor protein kinas ...... of intestinal epithelial cells
@nl
prefLabel
Tumor suppressor protein kinas ...... of intestinal epithelial cells
@ast
Tumor suppressor protein kinas ...... of intestinal epithelial cells
@en
Tumor suppressor protein kinas ...... of intestinal epithelial cells
@nl
P2093
P2860
P356
P1476
Tumor suppressor protein kinas ...... of intestinal epithelial cells
@en
P2093
Alexander Berezkin
Anna Zagryazhskaya
Byong Hoon Yoo
Kirill V. Rosen
Yanfei Wang
P2860
P304
P356
10.1002/IJC.26368
P577
2012-07-15T00:00:00Z