Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1)
about
Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transportersOligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix IIRole of the conserved glutamine 291 in the rat gamma-aminobutyric acid transporter rGAT-1The scaffolding protein PSD-95 interacts with the glycine transporter GLYT1 and impairs its internalizationGABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRETThe N terminus of monoamine transporters is a lever required for the action of amphetaminesConcentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D.The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA.The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C.The B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motif.Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies.Signal-dependent export of GABA transporter 1 from the ER-Golgi intermediate compartment is specified by a C-terminal motifAxonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulumSec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting.Functional coordination of alternative splicing in the mammalian central nervous systemA C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporterReticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization.Going with the flow: trafficking-dependent and -independent regulation of serotonin transport.GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation.The reverse operation of Na(+)/Cl(-)-coupled neurotransmitter transporters--why amphetamines take two to tango.Calcium dependent interaction of calmodulin with the GlyT1 C-terminus.A positive signal prevents secretory membrane cargo from recycling between the Golgi and the ER.The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle.PIN-G--a novel reporter for imaging and defining the effects of trafficking signals in membrane proteins.Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24CA cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter.Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism.Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters.SLC6 Transporter Folding Diseases and Pharmacochaperoning.Mechanisms and effects of retention of over-expressed aquaporin AtPIP2;1 in the endoplasmic reticulum.Truncated variants of pig somatostatin receptor subtype 5 (sst5) act as dominant-negative modulators for sst2-mediated signaling.Identification and characterization of the Fasciola hepatica sodium- and chloride-dependent taurine transporter.Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.
P2860
Q26825537-2B07AA8A-53E6-4337-8806-04CEF521749EQ28288845-316B1000-9E2A-49C4-B00D-753B13583221Q28569505-E9B31ACF-013E-4143-8865-E53BA9DE48E3Q28573212-3CF1CF46-D976-4E75-AF0B-B8B098BF6C54Q33590316-86F8194D-B945-49E1-8D94-4A1F000C275BQ33796294-4478EAF8-C1F4-462C-9005-DD26A6295233Q34599412-7DEAE5EA-011A-43A5-B745-F04CB3E7BC39Q34698077-9FD2AC95-F6A6-4569-B4D4-6F0B5594C833Q34963789-8504BECB-3BD4-48CB-B3AE-1299AD27DDB2Q35000777-AEE39596-40CA-4A68-AA8F-C3A639F41B7BQ35825535-E9807881-5A07-4738-B66F-46EBF8394074Q35836287-391A19E9-DBD5-44F7-8760-C847263FB229Q35836300-91260250-CC5D-400A-A0EA-8FF65B94457DQ35854905-EA36F5DB-14AD-40BD-B2A1-DD6C81527F5AQ36672416-686B158A-28E1-4542-82F7-CCB29B4A4A2EQ36822479-FC681A58-BEBC-4A05-AF57-C496D621054BQ36969111-B2A68317-1495-4025-AE42-97F324FCF2EDQ37004113-DA6C7BDB-5E96-4423-A080-DEE82C51E5D3Q37150439-BE503994-06A0-4379-9DE6-F808E38B9929Q37295076-B98C8A4E-B96B-4C2E-9C82-01E77F1ACA97Q37627941-4E1F14E0-4CAA-4BF9-AED1-D30373FEC934Q38962081-A8F9F725-2768-40FE-B96F-30DAAD7071AAQ38971512-55186C61-4774-403B-ACD5-60F0497582F2Q40306798-89F3DFF1-CAC8-4692-9551-C7CCDC6C9E43Q40307558-08A2D731-A1C6-4BE7-8CC0-596A3C93D5BEQ41175275-81C99F6B-7FF6-41D7-A04B-C32926969DB1Q41922717-7B26A758-1A35-42A9-A9D1-4BBD53DA8FCFQ42272217-11EDC12F-25F9-4847-B013-81C7B9F40A05Q47127983-070F70BC-A9DB-43FC-B70C-3299BC2C6F58Q47141268-F7BB6D3B-DBBC-4278-9827-48C4F0D596F8Q47585152-9CAE3150-0CCA-4F1E-9184-C29A6AED2FFCQ50530442-32835CEC-161B-437D-BE2B-1BFC32B3B549Q51756591-2A6462CA-838E-4860-8082-161CCB2B55B6Q53690843-41CC2ED8-5DB7-4BF8-81D1-158B86A7A223Q55361652-20E8976D-FE75-4A5D-BF51-72E8B2E5AD00
P2860
Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1)
description
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2004
@ast
im Juli 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/07/02)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/07/02)
@nl
наукова стаття, опублікована в липні 2004
@uk
name
Two discontinuous segments in ...... yric acid transporter-1 (GAT1)
@ast
Two discontinuous segments in ...... yric acid transporter-1 (GAT1)
@en
Two discontinuous segments in ...... yric acid transporter-1 (GAT1)
@nl
type
label
Two discontinuous segments in ...... yric acid transporter-1 (GAT1)
@ast
Two discontinuous segments in ...... yric acid transporter-1 (GAT1)
@en
Two discontinuous segments in ...... yric acid transporter-1 (GAT1)
@nl
prefLabel
Two discontinuous segments in ...... yric acid transporter-1 (GAT1)
@ast
Two discontinuous segments in ...... yric acid transporter-1 (GAT1)
@en
Two discontinuous segments in ...... yric acid transporter-1 (GAT1)
@nl
P2093
P2860
P50
P356
P1476
Two discontinuous segments in ...... yric acid transporter-1 (GAT1)
@en
P2093
Michael Freissmuth
Oliver Kudlacek
Verena Paulitschke
Vladimir M. Korkhov
P2860
P304
28553–28563
P356
10.1074/JBC.M307325200
P407
P577
2004-07-02T00:00:00Z