Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8
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AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complexMolecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling UnitsCaV1.2 signaling complexes in the heartThe physiology of protein S-acylationM-current preservation contributes to anticonvulsant effects of valproic acid.Dysregulated striatal neuronal processing and impaired motor behavior in mice lacking huntingtin interacting protein 14 (HIP14)AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors.Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits.The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmitoylation of AKAP79/150Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms.Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins.A-kinase anchoring proteins as potential drug targets.Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity"Shaping" of cell signaling via AKAP-tethered PDE4D: Probing with AKAR2-AKAP5 biosensor.Anchoring proteins as regulators of signaling pathways.A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.Creating order from chaos: cellular regulation by kinase anchoring.Regions on adenylyl cyclase VII required for selective regulation by the G13 pathwayResolving the kinetics of lipid, protein and peptide diffusion in membranes.Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.cAMP signaling in subcellular compartments.Adenylate cyclase-centred microdomains.Modulation of Kv7 channels and excitability in the brain.International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly.A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.The Spatiotemporal Regulation of cAMP Signaling in Blood Platelets-Old Friends and New PlayersDJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes.Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders.cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes.CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression.Lipids at membrane contact sites: cell signaling and ion transport.AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin.
P2860
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P2860
Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8
description
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2011
@ast
im September 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/09/23)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/09/23)
@nl
наукова стаття, опублікована у вересні 2011
@uk
name
Palmitoylation targets AKAP79 ...... sitive adenylyl cyclase type 8
@ast
Palmitoylation targets AKAP79 ...... sitive adenylyl cyclase type 8
@en
Palmitoylation targets AKAP79 ...... sitive adenylyl cyclase type 8
@nl
type
label
Palmitoylation targets AKAP79 ...... sitive adenylyl cyclase type 8
@ast
Palmitoylation targets AKAP79 ...... sitive adenylyl cyclase type 8
@en
Palmitoylation targets AKAP79 ...... sitive adenylyl cyclase type 8
@nl
prefLabel
Palmitoylation targets AKAP79 ...... sitive adenylyl cyclase type 8
@ast
Palmitoylation targets AKAP79 ...... sitive adenylyl cyclase type 8
@en
Palmitoylation targets AKAP79 ...... sitive adenylyl cyclase type 8
@nl
P2093
P2860
P3181
P356
P1476
Palmitoylation targets AKAP79 ...... sitive adenylyl cyclase type 8
@en
P2093
Debbie Willoughby
Dermot M. F. Cooper
Gerald R. V. Hammond
Gerald V. R. Hammond
Ilse Delint-Ramirez
Laura J. Ayling
P2860
P304
32962–32975
P3181
P356
10.1074/JBC.M111.243899
P407
P577
2011-09-23T00:00:00Z