Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsInduced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biologyGC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptorsGads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cellsSequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position.CSF-1 receptor signaling in myeloid cellsDistinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent.Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesisDysfunctional miRNA-Mediated Regulation in Chromophobe Renal Cell CarcinomaGab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells.Gab3 overexpression in human glioma mediates Akt activation and tumor cell proliferation.Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosisScaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops.Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina.Molecular live cell bioimaging in stem cell research.Gab adapter proteins as therapeutic targets for hematologic disease.Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor.Gene expression in IFN-gamma-activated murine macrophages.Purification and identification of protein-tyrosine kinase-binding proteins using synthetic phosphopeptides as affinity reagents.Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis.Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program.The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway.Gab1 signaling is regulated by EGF receptor sorting in early endosomes.Gab docking proteins in cardiovascular disease, cancer, and inflammation.The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions.Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.Interferon down-regulation of miR-1225-3p as an antiviral mechanism through modulating Grb2-associated binding protein 3 expression.
P2860
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P2860
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
description
2002 nî lūn-bûn
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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2002 թվականի հունվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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name
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation
@nl
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
@ast
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
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type
label
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation
@nl
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
@ast
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
@en
prefLabel
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation
@nl
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
@ast
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
@en
P2093
P2860
P921
P3181
P1476
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
@en
P2093
Brendan J Jenkins
Ingrid Wolf
Joseph M Custodio
Larry R Rohrschneider
Martina Seiffert
Paul Young
P2860
P304
P3181
P356
10.1128/MCB.22.1.231-244.2002
P407
P577
2002-01-01T00:00:00Z