Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice
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Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic developmentGenetically engineered mouse models of Parkinson's diseaseTyrosine hydroxylase and Parkinson's diseaseExpression of beta adrenergic receptors in mouse oocytes and preimplantation embryosCyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stabilityTargeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effectsA requirement for Gch1 and tetrahydrobiopterin in embryonic developmentBehavioral and monoamine changes following severe vitamin C deficiencyFetal effects of psychoactive drugsNeuroanatomical phenotyping in the mouse: the dopaminergic system.Regulation of pteridine-requiring enzymes by the cofactor tetrahydrobiopterin.Tetrahydrobiopterin in cardiovascular health and disease.Genomic imprinting and chromatin insulation in Beckwith-Wiedemann syndrome.Catecholamine biosynthesis and physiological regulation in neuroendocrine cells.Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice.Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification.Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure.Evidence for a critical role of catecholamines for cardiomyocyte lineage commitment in murine embryonic stem cells.An extended domain of Kcnq1ot1 silencing revealed by an imprinted fluorescent reporter.The catecholamine system in health and disease -Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes.Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projectionSatb1 ablation alters temporal expression of immediate early genes and reduces dendritic spine density during postnatal brain development.Deletion of tyrosine hydroxylase gene reveals functional interdependence of adrenocortical and chromaffin cell system in vivo.A new knock-in mouse model of l-DOPA-responsive dystonia.Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism.Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10.Dispensable, redundant, complementary, and cooperative roles of dopamine, octopamine, and serotonin in Drosophila melanogaster.The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease.High oxygen prevents fetal lethality due to lack of catecholaminesA tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene.Role of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumors with distinct catecholamine phenotypic features.The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.DNA demethylation by TDG.Complex molecular regulation of tyrosine hydroxylase.What does genetics tell us about imprinting and the placenta connection?Nucleotide sequence conservation of novel and established cis-regulatory sites within the tyrosine hydroxylase gene promoter.Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease.Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesisB6eGFPChAT mice overexpressing the vesicular acetylcholine transporter exhibit spontaneous hypoactivity and enhanced exploration in novel environments.
P2860
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P2860
Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice
description
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1995
@ast
im November 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1995/11/10)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/11/10)
@nl
наукова стаття, опублікована в листопаді 1995
@uk
name
Targeted disruption of the tyr ...... nd perinatal lethality in mice
@ast
Targeted disruption of the tyr ...... nd perinatal lethality in mice
@en
Targeted disruption of the tyr ...... nd perinatal lethality in mice
@nl
type
label
Targeted disruption of the tyr ...... nd perinatal lethality in mice
@ast
Targeted disruption of the tyr ...... nd perinatal lethality in mice
@en
Targeted disruption of the tyr ...... nd perinatal lethality in mice
@nl
prefLabel
Targeted disruption of the tyr ...... nd perinatal lethality in mice
@ast
Targeted disruption of the tyr ...... nd perinatal lethality in mice
@en
Targeted disruption of the tyr ...... nd perinatal lethality in mice
@nl
P2093
P2860
P356
P1476
Targeted disruption of the tyr ...... nd perinatal lethality in mice
@en
P2093
I. Nagatsu
K. Kobayashi
T. Mizuguchi
T. Nagatsu
Y. Watanabe
P2860
P304
27235–27243
P356
10.1074/JBC.270.45.27235
P407
P577
1995-11-10T00:00:00Z