A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
about
Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransductionClass III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusionsMouse class III myosins: kinase activity and phosphorylation sitesIntegrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associationsGenetics of auditory mechano-electrical transduction.Characterization and regulation of an additional actin-filament-binding site in large isoforms of the stereocilia actin-bundling protein espinMyosin III-mediated cross-linking and stimulation of actin bundling activity of Espin.MYO3A Causes Human Dominant Deafness and Interacts with Protocadherin 15-CD2 Isoform.Competition and compensation: dissecting the biophysical and functional differences between the class 3 myosin paralogs, myosins 3a and 3b.Myosin 3A kinase activity is regulated by phosphorylation of the kinase domain activation loop.Phosphorylation of the kinase domain regulates autophosphorylation of myosin IIIA and its translocation in microvilli.Impact of the Motor and Tail Domains of Class III Myosins on Regulating the Formation and Elongation of Actin ProtrusionsCharacterization of a novel MYO3A missense mutation associated with a dominant form of late onset hearing loss.
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A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
description
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
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im April 2011 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2011/04/01)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/04/01)
@nl
наукова стаття, опублікована у квітні 2011
@uk
مقالة علمية (نشرت في أبريل 2011)
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name
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
@ast
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
@en
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
@nl
type
label
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
@ast
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
@en
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
@nl
prefLabel
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
@ast
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
@en
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
@nl
P2093
P2860
P50
P1433
P1476
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA
@en
P2093
Amiel A. Dror
Dorith Raviv
Hashem Shahin
Moien N. Kanaan
Vanessa L. Walsh
P2860
P2888
P304
P356
10.1007/S00335-010-9310-6
P577
2011-04-01T00:00:00Z