Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype
about
TALE transcription factors during early development of the vertebrate brain and eyeCytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translationPbx homeodomain proteins pattern both the zebrafish retina and tectum.Cytosolic sequestration of Prep1 influences early stages of T cell development.Detection of differentially expressed genes between Erhualian and Large White placentas on day 75 and 90 of gestationImpact of genetic background on neonatal lethality of Gga2 gene-trap mice.Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1Regulation of CCL2 expression by an upstream TALE homeodomain protein-binding site that synergizes with the site created by the A-2578G SNP.Reduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesisTranscription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma.Misexpression of Pknox2 in mouse limb bud mesenchyme perturbs zeugopod development and deltoid crest formation.Induction of HoxB transcription by retinoic acid requires actin polymerization.Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability.The deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesisPrep1 (pKnox1) regulates mouse embryonic HSC cycling and self-renewal affecting the Stat1-Sca1 IFN-dependent pathway.ChIP-Seq and RNA-Seq analyses identify components of the Wnt and Fgf signaling pathways as Prep1 target genes in mouse embryonic stem cells.Genomic copy number variation in Mus musculusLoss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow.TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm.YAP controls retinal stem cell DNA replication timing and genomic stability.A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulationPrep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.Meis1 regulates Foxn4 expression during retinal progenitor cell differentiationHOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis.Pknox1/Prep1 regulates mitochondrial oxidative phosphorylation components in skeletal muscle.Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.Controlling Hox gene expression and activity to build the vertebrate axial skeleton.Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.Glimpse into Hox and tale regulation of cell differentiation and reprogramming.Glucose-induced expression of the homeotic transcription factor Prep1 is associated with histone post-translational modifications in skeletal muscle.Tumorigenesis by Meis1 overexpression is accompanied by a change of DNA target-sequence specificity which allows binding to the AP-1 elementA tale of TALE, PREP1, PBX1, and MEIS1: Interconnections and competition in cancer.MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proliferation and chemotherapy resistance.Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase.The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability.Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity.Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma.Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc lymphomagenesis: a tumor suppressor role for Prep1.Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress.
P2860
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P2860
Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype
description
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im August 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/08/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/08/01)
@nl
наукова стаття, опублікована в серпні 2006
@uk
مقالة علمية (نشرت في أغسطس 2006)
@ar
name
Hypomorphic mutation of the TA ...... leiotropic embryonic phenotype
@ast
Hypomorphic mutation of the TA ...... leiotropic embryonic phenotype
@en
Hypomorphic mutation of the TA ...... leiotropic embryonic phenotype
@nl
type
label
Hypomorphic mutation of the TA ...... leiotropic embryonic phenotype
@ast
Hypomorphic mutation of the TA ...... leiotropic embryonic phenotype
@en
Hypomorphic mutation of the TA ...... leiotropic embryonic phenotype
@nl
prefLabel
Hypomorphic mutation of the TA ...... leiotropic embryonic phenotype
@ast
Hypomorphic mutation of the TA ...... leiotropic embryonic phenotype
@en
Hypomorphic mutation of the TA ...... leiotropic embryonic phenotype
@nl
P2093
P2860
P921
P356
P1476
Hypomorphic mutation of the TA ...... leiotropic embryonic phenotype
@en
P2093
Annarita Miccio
Elena Longobardi
Elisabetta Ferretti
Francesco Blasi
Giuliana Ferrari
J. Carlos Villaescusa
Licia Selleri
Luis C. Fernandez-Diaz
Nicola Micali
Patrizia Di Rosa
P2860
P304
P356
10.1128/MCB.00313-06
P407
P577
2006-08-01T00:00:00Z