Identification of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease
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Pathophysiology of thrombotic thrombocytopenic purpuraMouse endogenous retroviruses can trigger premature transcriptional termination at a distanceNxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defectsShigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice.Microarray-based global mapping of integration sites for the retrotransposon, intracisternal A-particle, in the mouse genomeAllosteric activation of ADAMTS13 by von Willebrand factor.ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in miceFRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay.Cloning, expression and functional characterization of the full-length murine ADAMTS13.Molecular biology of ADAMTS13 and diagnostic utility of ADAMTS13 proteolytic activity and inhibitor assays.Insights into von Willebrand factor proteolysis: clinical implications.An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers.The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation.The first deletion mutation in the TSP1-6 repeat domain of ADAMTS13 in a family with inherited thrombotic thrombocytopenic purpura.The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice.Two novel heterozygote missense mutations of the ADAMTS13 gene in a child with recurrent thrombotic thrombocytopenic purpuraPlasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions.Distributions of transposable elements reveal hazardous zones in mammalian introns.Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor.Pathologic mechanisms of type 1 VWD mutations R1205H and Y1584C through in vitro and in vivo mouse models.Probing ADAMTS13 substrate specificity using phage displayGeneration of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura.ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in miceA genetically-engineered von Willebrand disease type 2B mouse model displays defects in hemostasis and inflammation.ADAMTS13 is expressed in hepatic stellate cells.Von Willebrand Factor Abnormalities Studied in the Mouse Model: What We Learned about VWF Functions.Modeling the neurovascular niche: murine strain differences mimic the range of responses to chronic hypoxia in the premature newborn.A splice variant of ADAMTS13 is expressed in human hepatic stellate cells and cancerous tissues.Use of a mouse model to elucidate the phenotypic effects of the von Willebrand factor cleavage mutants, Y1605A/M1606A and R1597W.
P2860
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P2860
Identification of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease
description
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2004
@ast
im Juli 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/07/16)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/07/16)
@nl
наукова стаття, опублікована в липні 2004
@uk
name
Identification of strain-speci ...... brand factor-cleaving protease
@ast
Identification of strain-speci ...... brand factor-cleaving protease
@en
Identification of strain-speci ...... brand factor-cleaving protease
@nl
type
label
Identification of strain-speci ...... brand factor-cleaving protease
@ast
Identification of strain-speci ...... brand factor-cleaving protease
@en
Identification of strain-speci ...... brand factor-cleaving protease
@nl
prefLabel
Identification of strain-speci ...... brand factor-cleaving protease
@ast
Identification of strain-speci ...... brand factor-cleaving protease
@en
Identification of strain-speci ...... brand factor-cleaving protease
@nl
P2093
P2860
P3181
P356
P1476
Identification of strain-speci ...... brand factor-cleaving protease
@en
P2093
Fumiaki Banno
Kazuyoshi Kaminaka
Kenji Soejima
Koichi Kokame
Toshiyuki Miyata
P2860
P304
30896–30903
P3181
P356
10.1074/JBC.M314184200
P407
P577
2004-07-16T00:00:00Z