The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
about
The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.Cilia in autophagy and cancerIns and outs of GPCR signaling in primary ciliaPrimary cilia in the developing and mature brainPrimary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengersZfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium FunctionConserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary SignalingIFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment.Intraflagellar transport complex structure and cargo interactions.Type 3 adenylyl cyclase: a key enzyme mediating the cAMP signaling in neuronal ciliaDisruption of G-protein γ5 subtype causes embryonic lethality in miceLack of dopaminergic inputs elongates the primary cilia of striatal neuronsPrimary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin ModelGpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviourAn siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genesTargeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia.Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.Trafficking to the primary cilium membrane.Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding.dTULP, the Drosophila melanogaster homolog of tubby, regulates transient receptor potential channel localization in cilia.New insights into an old organelle: meeting report on biology of cilia and flagellaFrom the cytoplasm into the cilium: bon voyage.Diverse cell type-specific mechanisms localize G protein-coupled receptors to Caenorhabditis elegans sensory ciliaCiliopathies: the trafficking connection.An assay for clogging the ciliary pore complex distinguishes mechanisms of cytosolic and membrane protein entry.The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.Whole-exome sequencing identifies homozygous GPR161 mutation in a family with pituitary stalk interruption syndrome.GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talkControlling fertilization and cAMP signaling in sperm by optogenetics.The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastomaInversion of Sonic hedgehog action on its canonical pathway by electrical activity.Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand.Proteomics of Primary Cilia by Proximity LabelingTargeting brain tumor cAMP: the case for sex-specific therapeuticsDopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary ciliaPhosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastomaCiliary Entry of the Hedgehog Transcriptional Activator Gli2 Is Mediated by the Nuclear Import Machinery but Differs from Nuclear Transport in Being Imp-α/β1-IndependentHedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation.Congenital Cataract in Gpr161vl/vl Mice Is Modified by Proximal Chromosome 15.The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling
P2860
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P2860
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
description
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
@ast
im Januar 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2013/01/17)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/01/17)
@nl
наукова стаття, опублікована в січні 2013
@uk
مقالة علمية (نشرت في 17-1-2013)
@ar
name
The ciliary G-protein-coupled ...... hog pathway via cAMP signaling
@ast
The ciliary G-protein-coupled ...... hog pathway via cAMP signaling
@en
The ciliary G-protein-coupled ...... hog pathway via cAMP signaling
@nl
type
label
The ciliary G-protein-coupled ...... hog pathway via cAMP signaling
@ast
The ciliary G-protein-coupled ...... hog pathway via cAMP signaling
@en
The ciliary G-protein-coupled ...... hog pathway via cAMP signaling
@nl
prefLabel
The ciliary G-protein-coupled ...... hog pathway via cAMP signaling
@ast
The ciliary G-protein-coupled ...... hog pathway via cAMP signaling
@en
The ciliary G-protein-coupled ...... hog pathway via cAMP signaling
@nl
P2093
P3181
P1433
P1476
The ciliary G-protein-coupled ...... hog pathway via cAMP signaling
@en
P2093
Alexander Loktev
Linda Rangell
Navneet Ratti
Peter K Jackson
Xiaohui Wen
P304
P3181
P356
10.1016/J.CELL.2012.12.026
P407
P577
2013-01-01T00:00:00Z