Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development
about
Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRbeta enhancer (Ebeta)Long-Range Regulation of V(D)J RecombinationRORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORgamma / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoterA nuclear matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expressionE proteins are required to activate germline transcription of the TCR Vbeta8.2 geneInitiation of V(D)J recombination by Dbeta-associated recombination signal sequences: a critical control point in TCRbeta gene assemblyGenomic analysis reveals extensive gene duplication within the bovine TRB locus.Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection.Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping.IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt.Ordered assembly of the V(D)J synaptic complex ensures accurate recombinationRegulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.Gene segment selection in V(D)J recombination: accessibility and beyond.V(D)J recombination frequency is affected by the sequence interposed between a pair of recombination signals: sequence comparison reveals a putative recombinational enhancer element.The center of accessibility: Dβ control of V(D)J recombinationLineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation.A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locusEnhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.Regulation of T-cell receptor beta-chain gene assembly by recombination signals: the beyond 12/23 restriction.Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development.Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription.An ectopic CTCF-dependent transcriptional insulator influences the choice of Vβ gene segments for VDJ recombination at TCRβ locus.Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.The interleukin 7 receptor is required for T cell receptor gamma locus accessibility to the V(D)J recombinase.Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination.A novel element upstream of the Vgamma2 gene in the murine T cell receptor gamma locus cooperates with the 3' enhancer to act as a locus control region.Turning T-cell receptor beta recombination on and off: more questions than answers.Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibilityEnhancer control of local accessibility to V(D)J recombinase.Expression of T-cell receptor genes during early T-cell development.The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombinationFunctional overlap in the cis-acting regulation of the V(D)J recombination at the TCRbeta locus.Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements.Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions.Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.Regulation of V(D)J recombination by transcriptional promoters.Evidence that immunoglobulin VH-DJ recombination does not require germ line transcription of the recombining variable gene segment.
P2860
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P2860
Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development
description
1996 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1996
@ast
im Juli 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/07/23)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/07/23)
@nl
наукова стаття, опублікована в липні 1996
@uk
name
Deletion of the mouse T-cell r ...... s alphabeta T-cell development
@ast
Deletion of the mouse T-cell r ...... s alphabeta T-cell development
@en
Deletion of the mouse T-cell r ...... s alphabeta T-cell development
@nl
type
label
Deletion of the mouse T-cell r ...... s alphabeta T-cell development
@ast
Deletion of the mouse T-cell r ...... s alphabeta T-cell development
@en
Deletion of the mouse T-cell r ...... s alphabeta T-cell development
@nl
prefLabel
Deletion of the mouse T-cell r ...... s alphabeta T-cell development
@ast
Deletion of the mouse T-cell r ...... s alphabeta T-cell development
@en
Deletion of the mouse T-cell r ...... s alphabeta T-cell development
@nl
P2093
P2860
P921
P3181
P356
P1476
Deletion of the mouse T-cell r ...... s alphabeta T-cell development
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.93.15.7877
P407
P577
1996-07-01T00:00:00Z