Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission
about
d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophreniaSerine racemase binds to PICK1: potential relevance to schizophreniaCharacterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of L-serine biosynthesisNew insights into neuron-glia communicationMolecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis.Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serineD-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptorInduction of serine racemase expression and D-serine release from microglia by amyloid beta-peptideRecent Updates on DTD (D-Tyr-tRNA(Tyr) Deacylase): An Enzyme Essential for Fidelity and Quality of Protein SynthesisA New Outlook on Mental Illnesses: Glial Involvement Beyond the GlueNMDA Receptor Function During Senescence: Implication on Cognitive PerformanceFunctional alterations of astrocytes in mental disorders: pharmacological significance as a drug targetA Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured AstrocytesImprovement in regional CBF by L-serine contributes to its neuroprotective effect in rats after focal cerebral ischemiaA new model for protein stereospecificityThe x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenationCrystal Structure of a Homolog of Mammalian Serine Racemase from Schizosaccharomyces pombeModulating the function of human serine racemase and human serine dehydratase by protein engineeringMetabolism of D-aminoacyl-tRNAs in Escherichia coli and Saccharomyces cerevisiae cells.The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophreniaTime and space profiling of NMDA receptor co-agonist functionsMouse brain serine racemase catalyzes specific elimination of L-serine to pyruvateD-Amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypusModulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemaseGlutamate receptor ion channels: structure, regulation, and functionSerine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activityA critical role for the glial-derived neuromodulator D-serine in the age-related deficits of cellular mechanisms of learning and memoryCharacterization of rapid and high-affinity uptake of L-serine in neurons and astrocytes in primary cultureNitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formationDirect calcium binding results in activation of brain serine racemaseA genome-wide association study identifies susceptibility variants for type 2 diabetes in Han ChineseD-Glutamate is metabolized in the heart mitochondria.Discordant behavioral effects of psychotomimetic drugs in mice with altered NMDA receptor functionGlutamatergic synaptic dysregulation in schizophrenia: therapeutic implications.Potential primary roles of glial cells in the mechanisms of psychiatric disorders.Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.Neonatal disruption of serine racemase causes schizophrenia-like behavioral abnormalities in adulthood: clinical rescue by d-serineIncreased concentrations of both NMDA receptor co-agonists D-serine and glycine in global ischemia: a potential novel treatment target for perinatal asphyxia.Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior
P2860
Q24294371-146EA5ED-38FC-417B-BE4A-A7032B0DEE0CQ24297355-58EFF6C4-548F-4F9E-815F-E31276540C4AQ24529988-059DD083-5FFF-4C18-8E29-CE6141FF3A6CQ24534045-3BDC926B-624F-484E-AB34-DBCA19D80F67Q24538921-ED33DF19-2673-424D-9769-31690E50C562Q24540400-5D0DD98D-B398-4B7C-92A2-77728A9640A4Q24675924-1F0D17B4-B3F5-4832-86EF-AC5AD557941EQ24794350-B4E9EFB8-8D7D-4617-86DB-0EF559E1A272Q26747250-8CC3413E-B459-4111-8F47-03EC2BBF505AQ26770756-CE24322A-06EC-4F32-BBBE-6F95D0D20B5FQ26770902-414DD489-7966-4C40-8D5B-BE6552C99A0DQ26798948-E21AA333-60DA-419C-A381-E569355E1635Q27307841-7CC4066F-05AC-47A9-8F24-0E8512B39391Q27312773-1AD793D7-498D-424E-8C23-FF792EBC2573Q27621545-CB793916-2F10-4E97-BBAD-037E6D7A1279Q27628036-6A0D32DB-9CDF-457E-AAB6-74BC134CE3A1Q27656759-ADD3F287-B748-4493-9F76-81E92C0DF762Q27683120-928D3CE5-3992-42FA-98B3-5F41FD997B12Q27930561-DBDCDC61-B999-415A-A9A5-CF14504276E8Q28081110-E718979D-D189-47C7-91B0-519AD7C641B1Q28084245-30BB9253-03AF-4916-9648-7FA29B75B6C6Q28206399-4D5A5F6F-8F9E-40C1-AC67-26AD2764822DQ28215680-CDFF8318-F8CB-418D-9B61-3A153B53DE21Q28241525-BB38FBA3-514C-4EE3-A9C0-A388FBC20E12Q28290774-F6F3E743-5110-41FA-AFA2-86A1828021B0Q28513330-E6760977-C337-4820-83DE-83EA3E65BF0BQ28571166-8FE82FBC-C644-4AB7-8B8E-2A6BE8B30036Q28582137-CEFFCCB1-2579-4502-97BA-A07962F2FF03Q28587310-D856512E-181B-475D-9E3C-21C9845AD412Q28588327-BC772D93-FF29-4D8B-B9B5-9755155845ACQ28943551-1DF86405-0F7E-47B4-842B-797C83E598D9Q30274552-AE989F2A-B695-42C1-8CB7-7EEAC640796BQ30386868-CE604C42-3373-49CB-A2EA-9F5D3702D536Q30387014-FA424606-1F5B-4887-9F3A-24EBC6AFF1F0Q30410688-48883DFA-9143-49D5-BA83-043979E9D160Q30447828-4E31E2D3-B4FE-4B9C-8846-20032C4F4720Q30455182-E65F83A9-9EE5-4F5F-94AD-783166576972Q30466599-3B593F86-6D0B-44CC-8942-22C6FAD917AAQ30473410-13A4AEB7-6C8E-480A-868C-6D436B0D2793Q30484413-6B2CD8CF-7E5F-4634-AB69-37E91ADC9673
P2860
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission
description
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1999
@ast
im November 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/11/09)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/11/09)
@nl
наукова стаття, опублікована в листопаді 1999
@uk
name
Serine racemase: a glial enzym ...... -D-aspartate neurotransmission
@ast
Serine racemase: a glial enzym ...... -D-aspartate neurotransmission
@en
Serine racemase: a glial enzym ...... -D-aspartate neurotransmission
@nl
type
label
Serine racemase: a glial enzym ...... -D-aspartate neurotransmission
@ast
Serine racemase: a glial enzym ...... -D-aspartate neurotransmission
@en
Serine racemase: a glial enzym ...... -D-aspartate neurotransmission
@nl
prefLabel
Serine racemase: a glial enzym ...... -D-aspartate neurotransmission
@ast
Serine racemase: a glial enzym ...... -D-aspartate neurotransmission
@en
Serine racemase: a glial enzym ...... -D-aspartate neurotransmission
@nl
P2093
P2860
P3181
P356
P1476
Serine racemase: a glial enzym ...... -D-aspartate neurotransmission
@en
P2093
H. Wolosker
S. Blackshaw
S. H. Snyder
P2860
P304
13409–13414
P3181
P356
10.1073/PNAS.96.23.13409
P407
P577
1999-11-09T00:00:00Z