Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
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Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channelNew molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channelsDiverse mechanisms of antiepileptic drugs in the development pipelineMolecular targets for antiepileptic drug developmentIon channels as drug targets in central nervous system disordersPathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studiesMolecular underpinnings of ventral surface chemoreceptor function: focus on KCNQ channelsRetigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 MutationsContribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currentsN-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of EpilepsyGenetics and epilepsy.Neonatal nonepileptic myoclonus is a prominent clinical feature of KCNQ2 gain-of-function variants R201C and R201H.Organization and maintenance of molecular domains in myelinated axonsUnraveling monogenic channelopathies and their implications for complex polygenic diseaseThe KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.Osteopenia due to enhanced cathepsin K release by BK channel ablation in osteoclasts.Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit.Channelopathies: ion channel defects linked to heritable clinical disorders.Potassium channels: how genetic studies of epileptic syndromes open paths to new therapeutic targets and drugs.The neuronal channelopathies.Effects of KCNQ2 gene truncation on M-type Kv7 potassium currentsThe kick-in system: a novel rapid knock-in strategy.Kv7.2 regulates the function of peripheral sensory neurons.A novel degradation signal derived from distal C-terminal frameshift mutations of KCNQ2 protein which cause neonatal epilepsy.Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine.Genetic mechanisms that underlie epilepsy.Diurnal Variation Has Effect on Differential Gene Expression Analysis in the Hippocampus of the Pilocarpine-Induced Model of Mesial Temporal Lobe Epilepsy.Neonatal epilepsy syndromes and GEFS+: mechanistic considerations.Epileptogenic channelopathies: experimental models of human pathologies.The cellular building blocks of breathingK+ channel modulators for the treatment of neurological disorders and autoimmune diseasesVoltage-gated potassium channels as therapeutic targets.Conditional deletions of epilepsy-associated KCNQ2 and KCNQ3 channels from cerebral cortex cause differential effects on neuronal excitabilityThe mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy.Mechanisms of activation of voltage-gated potassium channels.KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors.Chansporter complexes in cell signaling.Models for discovery of targeted therapy in genetic epileptic encephalopathies.Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption.Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming.
P2860
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P2860
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
description
2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
scientific journal article
@en
vedecký článok (publikovaný 2000/07/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/07/01)
@nl
наукова стаття, опублікована в липні 2000
@uk
مقالة علمية (نشرت في يوليو 2000)
@ar
name
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
@ast
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
@en
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
@nl
type
label
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
@ast
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
@en
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
@nl
prefLabel
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
@ast
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
@en
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
@nl
P2093
P1476
Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
@en
P2093
A. Kosakai
H. Watanabe
M. Nakamura
M. Yokoyama
P356
10.1046/J.1471-4159.2000.0750028.X
P407
P577
2000-07-01T00:00:00Z