The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease
about
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastasesNeuroendocrine secretory protein 7B2: structure, expression and functionsRegulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputsBinding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturationThe multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functionsProcessing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry.Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity.Altered neuropeptide profile of Caenorhabditis elegans lacking the chaperone protein 7B2 as analyzed by mass spectrometry.SUPPRESSOR OF LLP1 1-mediated C-terminal processing is critical for CLE19 peptide activity.Defective secretion of islet hormones in chromogranin-B deficient mice.Dopamine-regulated adrenocorticotropic hormone secretion in lactating rats: functional plasticity of melanotropes.Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion.Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands.Glucagon signaling modulates sweet taste responsiveness.Secretory plasticity of pituitary cells: a mechanism of hormonal regulation.Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesisGamma-MSH, sodium metabolism, and salt-sensitive hypertension.Melanotrope cells as a model to understand the (patho)physiological regulation of hormone secretion.The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation.Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype.The extended granin family: structure, function, and biomedical implicationsRegulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormoneProteases for processing proneuropeptides into peptide neurotransmitters and hormones.Discovery and progress in our understanding of the regulated secretory pathway in neuroendocrine cells.Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2.Pituitary protein 7B2 plasma levels in patients with liver disease: Comparisons with other hormones and neuropeptides.Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brainsGlucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion.Mutations in the catalytic domain of prohormone convertase 2 result in decreased binding to 7B2 and loss of inhibition with 7B2 C-terminal peptide.Single cell transcriptomic profiling of mouse pancreatic progenitors.Frequent epigenetic inactivation of the chaperone SGNE1/7B2 in human gliomas.Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3.Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion.The role of the 7B2 CT peptide in the inhibition of prohormone convertase 2 in endocrine cell lines.A 36-residue peptide contains all of the information required for 7B2-mediated activation of prohormone convertase 2.Strain-specific steroidal control of pituitary function.Tissue distribution and processing of proSAAS by proprotein convertases.Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice.
P2860
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P2860
The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease
description
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im März 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/03/05)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/03/05)
@nl
наукова стаття, опублікована в березні 1999
@uk
مقالة علمية (نشرت في 5-3-1999)
@ar
name
The neuroendocrine protein 7B2 ...... or pituitary Cushing's disease
@ast
The neuroendocrine protein 7B2 ...... or pituitary Cushing's disease
@en
The neuroendocrine protein 7B2 ...... or pituitary Cushing's disease
@nl
type
label
The neuroendocrine protein 7B2 ...... or pituitary Cushing's disease
@ast
The neuroendocrine protein 7B2 ...... or pituitary Cushing's disease
@en
The neuroendocrine protein 7B2 ...... or pituitary Cushing's disease
@nl
prefLabel
The neuroendocrine protein 7B2 ...... or pituitary Cushing's disease
@ast
The neuroendocrine protein 7B2 ...... or pituitary Cushing's disease
@en
The neuroendocrine protein 7B2 ...... or pituitary Cushing's disease
@nl
P2093
P1433
P1476
The neuroendocrine protein 7B2 ...... or pituitary Cushing's disease
@en
P2093
C. H. Westphal
D. F. Steiner
I. Lindberg
M. Schambelan
S. Bonner-Weir
P304
P356
10.1016/S0092-8674(00)80579-6
P407
P577
1999-03-05T00:00:00Z