Reverse evolution leads to genotypic incompatibility despite functional and active site convergence
about
Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.The role of protein dynamics in the evolution of new enzyme functionStructural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes.Causes of molecular convergence and parallelism in protein evolution.Functional Trade-Offs in Promiscuous Enzymes Cannot Be Explained by Intrinsic Mutational Robustness of the Native ActivityA Shorter Route to Antibody Binders via Quantitative in vitro Bead-Display Screening and Consensus Analysis.Resurrecting ancestral structural dynamics of an antiviral immune receptor: adaptive binding pocket reorganization repeatedly shifts RNA preference.Specificity Effects of Amino Acid Substitutions in Promiscuous Hydrolases: Context-Dependence of Catalytic Residue Contributions to Local Fitness Landscapes in Nearby Sequence Space.Directed evolution to improve the catalytic efficiency of urate oxidase from Bacillus subtilis.In Planta Recapitulation of Isoprene Synthases Evolution from Ocimene Synthases.Epistasis in protein evolution.Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations.How mutational epistasis impairs predictability in protein evolution and designCompensatory mutations and epistasis for protein function.Constrained evolution of a bispecific enzyme: lessons for biocatalyst design.Divergent and parallel routes of biochemical adaptation in high-altitude passerine birds from the Qinghai-Tibet Plateau.A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset
P2860
Q27343150-DAA3F01D-6897-4982-BA85-658A8C52C7C6Q27728043-BC0EAD13-01F3-492E-AA46-96FF3B52E8B8Q33650982-A5A17C5F-FC4C-462D-8B7D-5F4E586C2B89Q33829798-7D046A23-B034-4CFB-AB04-FC67415FB25FQ36157563-CAB45023-01CC-424A-BAB6-B75E19E15321Q36183984-CE805C57-9D11-436A-BB58-333F0E60DC17Q36185915-CCCAC0AF-9B0A-417B-A13F-D15395C10208Q36360999-696E27C7-50EE-41FC-9935-50B286432F49Q36377741-6DD3282C-25F1-4349-9574-F3D429C655DBQ36411598-5341CABB-2E80-477F-96D8-DB8D122238EEQ38718935-40C863EA-E0D4-4610-83B0-9BED2789E4A8Q38997863-1DC2AA85-64C5-49E2-9A3E-A00E7938D58BQ42197694-B516DF03-5A5B-4CFA-89F9-E35CC518B80AQ47383675-0CF06CDB-67CB-4A44-8D5B-642A2F28DDEAQ48093665-9F5A3EA2-E9E1-4D9E-8D0F-3D2AA1AD42CEQ50063680-B8DB63A0-3BF0-4C17-AC36-87E9D050AAABQ52338900-BF0708FB-4CEB-425D-889B-50D3BE1F065EQ56889432-5EACFFF7-D378-4309-9274-CF7DB74BFDB2
P2860
Reverse evolution leads to genotypic incompatibility despite functional and active site convergence
description
2015 nî lūn-bûn
@nan
2015 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Reverse evolution leads to gen ...... al and active site convergence
@ast
Reverse evolution leads to gen ...... al and active site convergence
@en
Reverse evolution leads to gen ...... al and active site convergence
@nl
type
label
Reverse evolution leads to gen ...... al and active site convergence
@ast
Reverse evolution leads to gen ...... al and active site convergence
@en
Reverse evolution leads to gen ...... al and active site convergence
@nl
prefLabel
Reverse evolution leads to gen ...... al and active site convergence
@ast
Reverse evolution leads to gen ...... al and active site convergence
@en
Reverse evolution leads to gen ...... al and active site convergence
@nl
P2860
P50
P3181
P356
P1433
P1476
Reverse evolution leads to gen ...... al and active site convergence
@en
P2093
Miriam Kaltenbach
Nobuhiko Tokuriki
P2860
P3181
P356
10.7554/ELIFE.06492
P407
P577
2015-08-14T00:00:00Z