ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms
about
Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signalingPhosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell linesNeuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand.The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous systemCharacterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampusA hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factorErbb2 is required for cardiac atrial electrical activity during developmentNeuregulin receptors, erbB3 and erbB4, are localized at neuromuscular synapsesThe cellular response to neuregulins is governed by complex interactions of the erbB receptor familyDiversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactionsErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancerErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network.DNA methylation changes in a human cell model of breast cancer progression.ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling.Bivalence of EGF-like ligands drives the ErbB signaling networkDifferential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers.Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factorSelective targeting and inducible destruction of human cancer cells by retroviruses with envelope proteins bearing short peptide ligandsSuppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake.The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zoneLocalization of phosphorylated ErbB1-4 and heregulin in colorectal cancerInhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3.Neuregulin 1 Improves Glucose Tolerance in db/db MiceEffects of in vivo heregulin beta1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancyActivity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brainAAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Laminin activates the p185HER2 oncoprotein and mediates growth inhibition of breast carcinoma cellsConstitutive proteolysis of the ErbB-4 receptor tyrosine kinase by a unique, sequential mechanism.The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors.ErbB2 expression increases the spectrum and potency of ligand-mediated signal transduction through ErbB4.Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2.Morphogenetic effects of neuregulin (neu differentiation factor) in cultured epithelial cells.The efficacy of Herceptin therapies is influenced by the expression of other erbB receptors, their ligands and the activation of downstream signalling proteinsBiochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor protein.Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia.Signal transduction by epidermal growth factor and heregulin via the kinase-deficient ErbB3 protein.Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis.Signaling by ERBB4Regulation of the prometastatic neuregulin-MMP13 axis by SRC family kinases: therapeutic implications.
P2860
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P2860
ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms
description
1994 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1994
@ast
im Oktober 1994 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1994/10/07)
@sk
vědecký článek publikovaný v roce 1994
@cs
wetenschappelijk artikel (gepubliceerd op 1994/10/07)
@nl
наукова стаття, опублікована в жовтні 1994
@uk
name
ErbB-3 and ErbB-4 function as ...... tion factor/heregulin isoforms
@ast
ErbB-3 and ErbB-4 function as ...... tion factor/heregulin isoforms
@en
ErbB-3 and ErbB-4 function as ...... tion factor/heregulin isoforms
@nl
type
label
ErbB-3 and ErbB-4 function as ...... tion factor/heregulin isoforms
@ast
ErbB-3 and ErbB-4 function as ...... tion factor/heregulin isoforms
@en
ErbB-3 and ErbB-4 function as ...... tion factor/heregulin isoforms
@nl
prefLabel
ErbB-3 and ErbB-4 function as ...... tion factor/heregulin isoforms
@ast
ErbB-3 and ErbB-4 function as ...... tion factor/heregulin isoforms
@en
ErbB-3 and ErbB-4 function as ...... tion factor/heregulin isoforms
@nl
P2093
P1476
ErbB-3 and ErbB-4 function as ...... tion factor/heregulin isoforms
@en
P2093
Karunagaran D
Levkowitz G
P304
25226-25233
P407
P50
P577
1994-10-01T00:00:00Z