MLL targets SET domain methyltransferase activity to Hox gene promoters - Test2 - elhamkhani - TriplyDB

MLL targets SET domain methyltransferase activity to Hox gene promoters

MLL targets SET domain methyltransferase activity to Hox gene promoters

http://www.wikidata.org/entity/Q28609771

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Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4 The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53 Identification of the MLL2 complex as a coactivator for estrogen receptor alpha Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis Modulation of 14-3-3 interaction with phosphorylated histone H3 by combinatorial modification patterns Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation New insight into the molecular mechanisms of MLL-associated leukemia Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP β/ζ signaling by menin On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex Global and Hox-specific roles for the MLL1 methyltransferase The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.The parafibromin tumor suppressor protein is part of a human Paf1 complex A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers Epigenetic control of embryonic stem cell fate Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein The SET-domain protein superfamily: protein lysine methyltransferases Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives The many faces of histone H3K79 methylation

P2860

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P2860

MLL targets SET domain methyltransferase activity to Hox gene promoters

http://www.wikidata.org/entity/Q28609771

description

2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2002

@ast

im November 2002 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2002/11/01)

@sk

vědecký článek publikovaný v roce 2002

@cs

wetenschappelijk artikel (gepubliceerd op 2002/11/01)

@nl

наукова стаття, опублікована в листопаді 2002

@uk

مقالة علمية (نشرت في نوفمبر 2002)

@ar

name

MLL targets SET domain methyltransferase activity to Hox gene promoters

@ast

MLL targets SET domain methyltransferase activity to Hox gene promoters

@en

MLL targets SET domain methyltransferase activity to Hox gene promoters

@nl

type

label

MLL targets SET domain methyltransferase activity to Hox gene promoters

@ast

MLL targets SET domain methyltransferase activity to Hox gene promoters

@en

MLL targets SET domain methyltransferase activity to Hox gene promoters

@nl

prefLabel

MLL targets SET domain methyltransferase activity to Hox gene promoters

@ast

MLL targets SET domain methyltransferase activity to Hox gene promoters

@en

MLL targets SET domain methyltransferase activity to Hox gene promoters

@nl

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S1097-2765(02)00741-4

P1433

P1476

MLL targets SET domain methyltransferase activity to Hox gene promoters

@en

P2093

C. David Allis

http://www.w3.org/2001/XMLSchema#string

Denise Gibbs

http://www.w3.org/2001/XMLSchema#string

Hugh W. Brock

http://www.w3.org/2001/XMLSchema#string

Jay L. Hess

http://www.w3.org/2001/XMLSchema#string

Mary Ellen Martin

http://www.w3.org/2001/XMLSchema#string

Thomas A. Milne

http://www.w3.org/2001/XMLSchema#string

P304

1107–1117

http://www.w3.org/2001/XMLSchema#string

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scholarly article

P3181

686550

http://www.w3.org/2001/XMLSchema#string

P356

10.1016/S1097-2765(02)00741-4

http://www.w3.org/2001/XMLSchema#string

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5

http://www.w3.org/2001/XMLSchema#string

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10

http://www.w3.org/2001/XMLSchema#string

P50

Charles David Allis

P577

2002-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

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11016972

http://www.w3.org/2001/XMLSchema#string

P698

12453418

http://www.w3.org/2001/XMLSchema#string

P921

Lysine (K)-specific methyltransferase 2A