The human bile salt export pump: characterization of substrate specificity and identification of inhibitors
about
Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variabilityBile acid transporters in health and diseaseBile acid transportersMissense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicingEvaluation of Aerosol Delivery of Nanosuspension for Pre-clinical Pulmonary Drug DeliveryDetergent screening and purification of the human liver ABC transporters BSEP (ABCB11) and MDR3 (ABCB4) expressed in the yeast Pichia pastorisThe role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type IIVectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pumpIntegration of preclinical and clinical data with pharmacokinetic modeling and simulation to evaluate fexofenadine as a probe for hepatobiliary transport function.Antitubercular therapy in patients with cirrhosis: challenges and optionsIdentification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substratesClinical application of transcriptional activators of bile salt transporters.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.A study of the relationship between serum bile acids and propranolol pharmacokinetics and pharmacodynamics in patients with liver cirrhosis and in healthy controls.Bile formation and secretion.Heterologous overexpression and mutagenesis of the human bile salt export pump (ABCB11) using DREAM (Directed REcombination-Assisted Mutagenesis).Intractable itch relieved by 4-phenylbutyrate therapy in patients with progressive familial intrahepatic cholestasis type 1Medical treatment of cholestatic liver diseases: From pathobiology to pharmacological targets.The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver diseaseDifferential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.The feline bile salt export pump: a structural and functional comparison with canine and human Bsep/BSEPAn updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters.Genetics of familial intrahepatic cholestasis syndromes.Influence of seeding density and extracellular matrix on bile Acid transport and mrp4 expression in sandwich-cultured mouse hepatocytes.A Comprehensive Evaluation of Steroid Metabolism in Women with Intrahepatic Cholestasis of Pregnancy.Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression.Prediction of drug-induced intrahepatic cholestasis: in vitro screening and QSAR analysis of drugs inhibiting the human bile salt export pump.Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes.Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pumpBiosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.Intrahepatic cholestasis of pregnancy-current achievements and unsolved problemsBile Acid sulfation: a pathway of bile acid elimination and detoxification.Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion.Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and Management.A guide to the management of tuberculosis in patients with chronic liver disease.Role of the bile salt export pump, BSEP, in acquired forms of cholestasis.Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis.Canalicular ABC transporters and liver disease.
P2860
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P2860
The human bile salt export pump: characterization of substrate specificity and identification of inhibitors
description
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im November 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/11/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/11/01)
@nl
наукова стаття, опублікована в листопаді 2002
@uk
مقالة علمية (نشرت في نوفمبر 2002)
@ar
name
The human bile salt export pum ...... d identification of inhibitors
@ast
The human bile salt export pum ...... d identification of inhibitors
@en
The human bile salt export pum ...... d identification of inhibitors
@nl
type
label
The human bile salt export pum ...... d identification of inhibitors
@ast
The human bile salt export pum ...... d identification of inhibitors
@en
The human bile salt export pum ...... d identification of inhibitors
@nl
prefLabel
The human bile salt export pum ...... d identification of inhibitors
@ast
The human bile salt export pum ...... d identification of inhibitors
@en
The human bile salt export pum ...... d identification of inhibitors
@nl
P2093
P3181
P356
P1433
P1476
The human bile salt export pum ...... d identification of inhibitors
@en
P2093
Christopher F. Higgins
Giorgina Mieli-Vergani
Jane A. Byrne
Kenneth J. Linton
Richard J. Thompson
Sandra S. Strautnieks
P304
P3181
P356
10.1053/GAST.2002.36591
P407
P577
2002-11-01T00:00:00Z