C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state
about
Neurotransmitter release: the last millisecond in the life of a synaptic vesicleDynamics and Membrane Interactions of Protein Kinase CMembrane dynamics during cellular wound repair.Structural and mechanistic insights into the association of PKC -C2 domain to PtdIns(4,5)P2Pb 2+ as Modulator of Protein–Membrane InteractionsCd 2+ as a Ca 2+ Surrogate in Protein–Membrane Interactions: Isostructural but Not IsofunctionalA spatiotemporally coordinated cascade of protein kinase C activation controls isoform-selective translocation.PKCalpha: a versatile key for decoding the cellular calcium toolkit.Ca2+ influx and protein scaffolding via TRPC3 sustain PKCbeta and ERK activation in B cellsThe calcium binding loops of the cytosolic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cellsSingle-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-αC2-domain mediated nano-cluster formation increases calcium signaling efficiency.A new principle for information storage in an enzymatic pathway model.Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.Use of EPR power saturation to analyze the membrane-docking geometries of peripheral proteins: applications to C2 domainsProtein kinase C is a calcium sensor for presynaptic short-term plasticity.Protein kinase C-induced phosphorylation of Orai1 regulates the intracellular Ca2+ level via the store-operated Ca2+ channel.Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domainTrafficking of kainate receptors.The cPLA2 C2alpha domain in solution: structure and dynamics of its Ca2+-activated and cation-free statesMembrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: a combined molecular dynamics and experimental study.Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held.Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function.Ca2+ activation of the cPLA2 C2 domain: ordered binding of two Ca2+ ions with positive cooperativity.Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα.Calcium in red blood cells-a perilous balance.Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigmConfiguration of PKCalpha-C2 domain bound to mixed SOPC/SOPS lipid monolayers.Insights into a molecular switch that gates sensory neuron synapses during habituation in Aplysia.Protein kinase C: the "masters" of calcium and lipid.Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7Classical protein kinases C are regulated by concerted interaction with lipids: the importance of phosphatidylinositol-4,5-bisphosphate.PKCα diffusion and translocation are independent of an intact cytoskeletonSingle-cell resolution of intracellular T cell Ca2+ dynamics in response to frequency-based H2O2 stimulation.C2-domain containing calcium sensors in neuroendocrine secretion.Targeted activation of conventional and novel protein kinases C through differential translocation patternsCalcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held.Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation studyPKC-dependent autoregulation of membrane kainate receptors.Membrane-docking loops of the cPLA2 C2 domain: detailed structural analysis of the protein-membrane interface via site-directed spin-labeling.
P2860
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P2860
C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state
description
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im September 2002 veröffentlicher wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/09/24)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/09/24)
@nl
наукова стаття, опублікована у вересні 2002
@uk
مقالة علمية (نشرت في 24-9-2002)
@ar
name
C2 domains of protein kinase C ...... es of the membrane-bound state
@ast
C2 domains of protein kinase C ...... es of the membrane-bound state
@en
C2 domains of protein kinase C ...... es of the membrane-bound state
@nl
type
label
C2 domains of protein kinase C ...... es of the membrane-bound state
@ast
C2 domains of protein kinase C ...... es of the membrane-bound state
@en
C2 domains of protein kinase C ...... es of the membrane-bound state
@nl
prefLabel
C2 domains of protein kinase C ...... es of the membrane-bound state
@ast
C2 domains of protein kinase C ...... es of the membrane-bound state
@en
C2 domains of protein kinase C ...... es of the membrane-bound state
@nl
P2093
P2860
P3181
P356
P1433
P1476
C2 domains of protein kinase C ...... es of the membrane-bound state
@en
P2093
Joseph J Falke
Juan C Goméz-Fernandéz
Senena Corbalán-García
P2860
P304
11411-11424
P3181
P356
10.1021/BI026041K
P407
P577
2002-09-01T00:00:00Z