Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities
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RNase H activity: structure, specificity, and function in reverse transcriptionMurine leukemia virus reverse transcriptase: structural comparison with HIV-1 reverse transcriptaseRibonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionCoordination between the polymerase and RNase H activity of HIV-1 reverse transcriptaseMultiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H.Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.Actinomycin D inhibits human immunodeficiency virus type 1 minus-strand transfer in in vitro and endogenous reverse transcriptase assays.Relative rates of retroviral reverse transcriptase template switching during RNA- and DNA-dependent DNA synthesis.Molecular requirements for human immunodeficiency virus type 1 plus-strand transfer: analysis in reconstituted and endogenous reverse transcription systems.Factors that determine the efficiency of HIV-1 strand transfer initiated at a specific siteThe P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5'-end- and DNA 3'-end-directed RNase H activitiesReplication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase.RNase H cleavage of the 5' end of the human immunodeficiency virus type 1 genome.Mechanism analysis indicates that recombination events in HIV-1 initiate and complete over short distances, explaining why recombination frequencies are similar in different sections of the genomeMutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture.Domain structure of the human immunodeficiency virus reverse transcriptase.Dynamic copy choice: steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation.HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.Novel aptamer inhibitors of human immunodeficiency virus reverse transcriptase.Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H.Relationship between plus strand DNA synthesis removal of downstream segments of RNA by human immunodeficiency virus, murine leukemia virus and avian myeloblastoma virus reverse transcriptasesHIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.Specific cleavages by RNase H facilitate initiation of plus-strand RNA synthesis by Moloney murine leukemia virus.Mechanisms and factors that influence high frequency retroviral recombinationUnique progressive cleavage mechanism of HIV reverse transcriptase RNase HSiRNA-induced mutation in HIV-1 polypurine tract region and its influence on viral fitness.Requirements for efficient minus strand strong-stop DNA transfer in human immunodeficiency virus 1.The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in repEffects on DNA synthesis and translocation caused by mutations in the RNase H domain of Moloney murine leukemia virus reverse transcriptaseE- vectors: development of novel self-inactivating and self-activating retroviral vectors for safer gene therapy.What is the orientation of DNA polymerases on their templates?Sequence and structural determinants required for priming of plus-strand DNA synthesis by the human immunodeficiency virus type 1 polypurine tract.Human immunodeficiency virus type 1 nucleocapsid protein reduces reverse transcriptase pausing at a secondary structure near the murine leukemia virus polypurine tract.RNase H domain of Moloney murine leukemia virus reverse transcriptase retains activity but requires the polymerase domain for specificity.Human immunodeficiency virus type 1 nucleocapsid protein promotes efficient strand transfer and specific viral DNA synthesis by inhibiting TAR-dependent self-priming from minus-strand strong-stop DNA.Sequence-independent RNA cleavages generate the primers for plus strand DNA synthesis in hepatitis B viruses: implications for other reverse transcribing elements.Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine.RNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-template
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Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities
description
1991 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1991
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im Januar 1991 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1991/01/05)
@sk
vědecký článek publikovaný v roce 1991
@cs
wetenschappelijk artikel (gepubliceerd op 1991/01/05)
@nl
наукова стаття, опублікована в січні 1991
@uk
name
Reverse transcriptase.RNase H ...... and RNA hydrolysis activities
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Reverse transcriptase.RNase H ...... and RNA hydrolysis activities
@en
Reverse transcriptase.RNase H ...... and RNA hydrolysis activities
@nl
type
label
Reverse transcriptase.RNase H ...... and RNA hydrolysis activities
@ast
Reverse transcriptase.RNase H ...... and RNA hydrolysis activities
@en
Reverse transcriptase.RNase H ...... and RNA hydrolysis activities
@nl
prefLabel
Reverse transcriptase.RNase H ...... and RNA hydrolysis activities
@ast
Reverse transcriptase.RNase H ...... and RNA hydrolysis activities
@en
Reverse transcriptase.RNase H ...... and RNA hydrolysis activities
@nl
P1476
Reverse transcriptase.RNase H ...... and RNA hydrolysis activities
@en
P2093
E. S. Furfine
J. E. Reardon
P304
P407
P577
1991-01-05T00:00:00Z