Identification of the fusion peptide of primate immunodeficiency viruses
about
Multimeric CD4 binding exhibited by human and simian immunodeficiency virus envelope protein dimersNovel approaches to inhibit HIV entryMembrane interface-interacting sequences within the ectodomain of the human immunodeficiency virus type 1 envelope glycoprotein: putative role during viral fusionStructure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry InhibitorsPeptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infectionA synthetic all D-amino acid peptide corresponding to the N-terminal sequence of HIV-1 gp41 recognizes the wild-type fusion peptide in the membrane and inhibits HIV-1 envelope glycoprotein-mediated cell fusionHIV-1 Env C2-V4 diversification in a slow-progressor infant reveals a flat but rugged fitness landscapeCharacterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41The ectodomain of HIV-1 env subunit gp41 forms a soluble, alpha-helical, rod-like oligomer in the absence of gp120 and the N-terminal fusion peptideC-terminal tail of human immunodeficiency virus gp41: functionally rich and structurally enigmatic.High-throughput screening method of inhibitors that block the interaction between 2 helical regions of HIV-1 gp41.The membrane-proximal fusion domain of HIV-1 GP41 reveals sequence-specific and fine-tuning mechanism of membrane binding.Hexapeptides that interfere with HIV-1 fusion peptide activity in liposomes block GP41-mediated membrane fusion.Novel mechanistic insights into viral modulation of immune receptor signaling.A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity.The conserved glycine-rich segment linking the N-terminal fusion peptide to the coiled coil of human T-cell leukemia virus type 1 transmembrane glycoprotein gp21 is a determinant of membrane fusion function.Phenotype-associated env gene variation among eight related human immunodeficiency virus type 1 clones: evidence for in vivo recombination and determinants of cytotropism outside the V3 domain.Mutational analysis of residues in the coiled-coil domain of human immunodeficiency virus type 1 transmembrane protein gp41Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike proteinInteraction with CD4 and antibodies to CD4-induced epitopes of the envelope gp120 from a microglial cell-adapted human immunodeficiency virus type 1 isolateFailure To cleave murine leukemia virus envelope protein does not preclude its incorporation in virions and productive virus-receptor interactionMutational analysis of the putative fusion domain of Ebola virus glycoprotein.Studies on the fusion peptide of a paramyxovirus fusion glycoprotein: roles of conserved residues in cell fusion.Identification and characterization of fusion and processing domains of the human immunodeficiency virus type 2 envelope glycoprotein.Contribution of intrinsic reactivity of the HIV-1 envelope glycoproteins to CD4-independent infection and global inhibitor sensitivity.The tale of the long tail: the cytoplasmic domain of HIV-1 gp41.Retromer regulates HIV-1 envelope glycoprotein trafficking and incorporation into virions.The SCHOOL of nature: III. From mechanistic understanding to novel therapiesRational site-directed mutations of the LLP-1 and LLP-2 lentivirus lytic peptide domains in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41 indicate common functions in cell-cell fusion but distinct roles in virion envelope incStudy of the HIV-2 Env cytoplasmic tail variability and its impact on Tat, Rev and Nef.Enhanced dynamics of HIV gp120 glycoprotein by small molecule bindingHIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation.Temperature dependence of cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1.Mutations within a putative cysteine loop of the transmembrane protein of an attenuated immunodeficiency-inducing feline leukemia virus variant inhibit envelope protein processing.Membrane permeabilization by different regions of the human immunodeficiency virus type 1 transmembrane glycoprotein gp41Lipid membrane fusion induced by the human immunodeficiency virus type 1 gp41 N-terminal extremity is determined by its orientation in the lipid bilayerThe amino-terminal fusion domain peptide of human immunodeficiency virus type 1 gp41 inserts into the sodium dodecyl sulfate micelle primarily as a helix with a conserved glycine at the micelle-water interface.The cytopathicity of a simian immunodeficiency virus Mne variant is determined by mutations in Gag and Env.Theoretical and functional analysis of the SIV fusion peptideHIV-1 fusion peptide decreases bending energy and promotes curved fusion intermediates.
P2860
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P2860
Identification of the fusion peptide of primate immunodeficiency viruses
description
1989 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1989
@ast
im Mai 1989 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1989/05/12)
@sk
vědecký článek publikovaný v roce 1989
@cs
wetenschappelijk artikel (gepubliceerd op 1989/05/12)
@nl
наукова стаття, опублікована в травні 1989
@uk
name
Identification of the fusion peptide of primate immunodeficiency viruses
@ast
Identification of the fusion peptide of primate immunodeficiency viruses
@en
Identification of the fusion peptide of primate immunodeficiency viruses
@nl
type
label
Identification of the fusion peptide of primate immunodeficiency viruses
@ast
Identification of the fusion peptide of primate immunodeficiency viruses
@en
Identification of the fusion peptide of primate immunodeficiency viruses
@nl
prefLabel
Identification of the fusion peptide of primate immunodeficiency viruses
@ast
Identification of the fusion peptide of primate immunodeficiency viruses
@en
Identification of the fusion peptide of primate immunodeficiency viruses
@nl
P2093
P3181
P356
P1433
P1476
Identification of the fusion peptide of primate immunodeficiency viruses
@en
P2093
F. Giombini
F. Wong-Staal
G. Franchini
K. Fargnoli
M. L. Bosch
P. L. Earl
S. Picciafuoco
P304
P3181
P356
10.1126/SCIENCE.2541505
P407
P577
1989-05-12T00:00:00Z