Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors
about
PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical dataPI3K and cancer: lessons, challenges and opportunitiesSelective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferationThe PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models.Genetically engineered mouse models of PI3K signaling in breast cancer.Paradoxical zinc toxicity and oxidative stress in the mammary gland during marginal dietary zinc deficiency.Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies.Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R.Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer.Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells.Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammary tumors.Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment.Inhibitors of STAT3, β-catenin, and IGF-1R sensitize mouse PIK3CA-mutant breast cancer to PI3K inhibitors.Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions.P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer.Cancer-Associated PIK3CA Mutations in Overgrowth Disorders
P2860
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P2860
Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Physiological levels of Pik3ca ...... rmation of ERα-positive tumors
@ast
Physiological levels of Pik3ca ...... rmation of ERα-positive tumors
@en
Physiological levels of Pik3ca ...... rmation of ERα-positive tumors
@nl
type
label
Physiological levels of Pik3ca ...... rmation of ERα-positive tumors
@ast
Physiological levels of Pik3ca ...... rmation of ERα-positive tumors
@en
Physiological levels of Pik3ca ...... rmation of ERα-positive tumors
@nl
prefLabel
Physiological levels of Pik3ca ...... rmation of ERα-positive tumors
@ast
Physiological levels of Pik3ca ...... rmation of ERα-positive tumors
@en
Physiological levels of Pik3ca ...... rmation of ERα-positive tumors
@nl
P2093
P2860
P1433
P1476
Physiological levels of Pik3ca ...... rmation of ERα-positive tumors
@en
P2093
Anjali Tikoo
Ivan Ivetac
Karen G Montgomery
Lauren Hare
Mark Shackleton
Paul Waring
Rebecca Pelzer
Vincent Roh
P2860
P304
P356
10.1371/JOURNAL.PONE.0036924
P407
P577
2012-05-30T00:00:00Z