Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis
about
New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomasMDM2 is an important prognostic and predictive factor for platin-pemetrexed therapy in malignant pleural mesotheliomas and deregulation of P14/ARF (encoded by CDKN2A) seems to contribute to an MDM2-driven inactivation of P53.Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesotheliomaAn asbestos-exposed family with multiple cases of pleural malignant mesothelioma without inheritance of a predisposing BAP1 mutationLatest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapiesIntegrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines.Whole exome sequencing of an asbestos-induced wild-type murine model of malignant mesothelioma.Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma.Zoledronic acid produces combinatory anti-tumor effects with cisplatin on mesothelioma by increasing p53 expression levels.Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma.Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice.53BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathwayInflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma.CELLFOOD™ induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways.Pathological and molecular biological approaches to early mesothelioma.Molecular pathogenesis of malignant mesothelioma.Five years update on relationships between malignant pleural mesothelioma and exposure to asbestos and other elongated mineral particles.Tumor suppressor alterations cooperate to drive aggressive mesotheliomas with enriched cancer stem cells via a p53-miR-34a-c-Met axis.Chrysotile effects on the expression of anti-oncogene P53 and P16 and oncogene C-jun and C-fos in Wistar rats' lung tissues.Lung function not affected by asbestos exposure in workers with normal Computed Tomography scan.Heterogeneous Contributing Factors in MPM Disease Development and Progression: Biological Advances and Clinical Implications.New Perspectives on Diagnosis and Therapy of Malignant Pleural Mesothelioma.
P2860
Q26859274-91B7829D-998D-478A-8D6E-65C67A8BA24EQ27853125-976D9A7D-E782-4B2E-8FDE-FE06D5782B29Q28389071-110BFEB0-1989-4572-BE52-CA94AA0E53A9Q28391365-9AC15F9C-6AF0-4DEE-B0D7-8F00ACE42F55Q28395597-C96A3D42-5541-4652-9E3C-7BCC7C17A9A6Q33648515-A0B7DB1B-6B11-4F5F-9CAB-71D9D1DF0260Q33755896-7A47012F-4741-48A2-AB7D-019632B356EEQ34194566-56D38D0C-246B-4F44-8575-1176069456C2Q34653709-68700B82-D043-40E9-918F-57D1D7D63D70Q35604575-D53D87C7-07BC-4213-9200-E5F0EFA4CBF9Q36557014-F5E8652B-28C9-4C7D-80B0-6659A69BB574Q36642343-9A83AC40-8A7D-46B0-A858-3E20E9D51BF4Q36863203-5E72A03D-52B5-4329-AF16-864F39C65053Q37684694-7CA890EA-D5F4-4FEA-A002-0D5502519CB7Q37975137-AACC64A1-6C50-49B0-9C96-ADD08B9647FEQ38107102-4F736310-3FFA-4CB5-91F2-5A0D59D7246EQ38972707-054F559E-7B7B-4389-AA2F-C7D46C2732D9Q42006082-605ECAC6-A849-46B0-BCFE-97A0DCF94FB5Q43365116-C2D5227E-AD29-4A78-B64A-E4126B885B80Q47929433-AAD175A0-B88F-49D6-A8BB-54290B09E955Q49996923-B197752B-2709-4CBE-A793-0F6844BFCE58Q52581757-47888ED5-9C39-4765-A094-FC23E68F0106
P2860
Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Losses of both products of the ...... te to accelerate tumorigenesis
@ast
Losses of both products of the ...... te to accelerate tumorigenesis
@en
Losses of both products of the ...... te to accelerate tumorigenesis
@nl
type
label
Losses of both products of the ...... te to accelerate tumorigenesis
@ast
Losses of both products of the ...... te to accelerate tumorigenesis
@en
Losses of both products of the ...... te to accelerate tumorigenesis
@nl
prefLabel
Losses of both products of the ...... te to accelerate tumorigenesis
@ast
Losses of both products of the ...... te to accelerate tumorigenesis
@en
Losses of both products of the ...... te to accelerate tumorigenesis
@nl
P2093
P2860
P1433
P1476
Losses of both products of the ...... te to accelerate tumorigenesis
@en
P2093
Andres J Klein-Szanto
Ara Tadevosyan
Craig W Menges
Deborah A Altomare
Erin Neumann-Domer
Ilse Chudoba
Jianming Pei
Joseph R Testa
Lili Zhang
P2860
P304
P356
10.1371/JOURNAL.PONE.0018828
P407
P577
2011-04-19T00:00:00Z