Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study
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Approaches to preventative and therapeutic HIV vaccinesConsensus HIV-1 FSU-A integrase gene variants electroporated into mice induce polyfunctional antigen-specific CD4+ and CD8+ T cellsCTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV controlHIV-1 Vaccine Trials: Evolving Concepts and DesignsAltered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.HIV-1 vaccines: challenges and new perspectivesNovel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccinesNovel directions in HIV-1 vaccines revealed from clinical trialsIntra- and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trialsA phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults.Challenges in the design of a T cell vaccine in the context of HIV-1 diversity.Comparison on virulence and immunogenicity of two recombinant vaccinia vaccines, Tian Tan and Guang9 strains, expressing the HIV-1 envelope gene.Superior control of HIV-1 replication by CD8+ T cells targeting conserved epitopes: implications for HIV vaccine designHIV-1 vaccine-induced T-cell responses cluster in epitope hotspots that differ from those induced in natural infection with HIV-1.Broad HIV epitope specificity and viral inhibition induced by multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adultsIdentification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses.A Phase I Double Blind, Placebo-Controlled, Randomized Study of the Safety and Immunogenicity of an Adjuvanted HIV-1 Gag-Pol-Nef Fusion Protein and Adenovirus 35 Gag-RT-Int-Nef Vaccine in Healthy HIV-Uninfected African Adults.Impact of vaccination on cytotoxic T lymphocyte immunodominance and cooperation against simian immunodeficiency virus replication in rhesus macaques.HIV DNA Vaccine: Stepwise Improvements Make a Difference.Profile of T cell recognition of HIV type 1 consensus group M Gag and Nef peptides in a clade A1- and D-infected Ugandan population.Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials.A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challengeNew prospects for a preventive HIV-1 vaccine.Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection.Development of prophylactic vaccines against HIV-1.Evolutionarily conserved epitopes on human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus reverse transcriptases detected by HIV-1-infected subjectsBroad HIV-1 inhibition in vitro by vaccine-elicited CD8(+) T cells in African adults.Enhancement of viral escape in HIV-1 Nef by STEP vaccination.The Significance of Interferon-γ in HIV-1 Pathogenesis, Therapy, and Prophylaxis.HIV/AIDS: 30 years of progress and future challenges.Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines.Conserved immunogens in prime-boost strategies for the next-generation HIV-1 vaccines.HIV-1 Conserved Mosaics Delivered by Regimens with Integration-Deficient DC-Targeting Lentiviral Vector Induce Robust T Cells.Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys.Synthetic biology approach for the development of conditionally replicating HIV-1 vaccine.Impaired Nef function is associated with early control of HIV-1 viremia.Co-delivery of LIGHT expression plasmid enhances humoral and cellular immune responses to HIV-1 Nef in mice.A DNA-based candidate HIV vaccine delivered via in vivo electroporation induces CD4 responses toward the α4β7-binding V2 loop of HIV gp120 in healthy volunteers.Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection.The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection
P2860
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P2860
Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Mapping HIV-1 vaccine induced ...... ine efficacy in the Step study
@ast
Mapping HIV-1 vaccine induced ...... ine efficacy in the Step study
@en
Mapping HIV-1 vaccine induced ...... ine efficacy in the Step study
@nl
type
label
Mapping HIV-1 vaccine induced ...... ine efficacy in the Step study
@ast
Mapping HIV-1 vaccine induced ...... ine efficacy in the Step study
@en
Mapping HIV-1 vaccine induced ...... ine efficacy in the Step study
@nl
prefLabel
Mapping HIV-1 vaccine induced ...... ine efficacy in the Step study
@ast
Mapping HIV-1 vaccine induced ...... ine efficacy in the Step study
@en
Mapping HIV-1 vaccine induced ...... ine efficacy in the Step study
@nl
P2093
P2860
P50
P3181
P1433
P1476
Mapping HIV-1 vaccine induced ...... ine efficacy in the Step study
@en
P2093
Bette T M Korber
Danilo R Casimiro
Fusheng Li
James Szinger
John W Shiver
Sheri A Dubey
Steven G Self
Suzanne Cole
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0020479
P407
P577
2011-01-01T00:00:00Z