Determinants of protein function revealed by combinatorial entropy optimization
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Protein 3D structure computed from evolutionary sequence variationGermline mutations in BAP1 predispose to melanocytic tumorsInitial genome sequencing and analysis of multiple myelomaComputational and statistical approaches to analyzing variants identified by exome sequencingIntegrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinomaGetting personalized cancer genome analysis into the clinic: the challenges in bioinformaticsRational mutational analysis of a multidrug MFS transporter CaMdr1p of Candida albicans by employing a membrane environment based computational approachGenome Sequence Variability Predicts Drug Precautions and Withdrawals from the MarketUsing bioinformatics to predict the functional impact of SNVsPartially-supervised protein subclass discovery with simultaneous annotation of functional residues.Exploring the structure and function paradigm.The observation of evolutionary interaction pattern pairs in membrane proteins.Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association StudiesPrediction of missense mutation functionality depends on both the algorithm and sequence alignment employedMutations in apoptosis-inducing factor cause X-linked recessive auditory neuropathy spectrum disorderThe genetic landscape of mutations in Burkitt lymphoma.Combining specificity determining and conserved residues improves functional site predictionProtein interactions and ligand binding: from protein subfamilies to functional specificity.Using shifts in amino acid frequency and substitution rate to identify latent structural characters in base-excision repair enzymesThe FGGY carbohydrate kinase family: insights into the evolution of functional specificitiesMUFFINN: cancer gene discovery via network analysis of somatic mutation data.Differences in evolutionary pressure acting within highly conserved ortholog groupsCoevolution in defining the functional specificity.Ensemble approach to predict specificity determinants: benchmarking and validationDetermining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics.Sequence variations of the EGR4 gene in Korean men with spermatogenesis impairment.An automated stochastic approach to the identification of the protein specificity determinants and functional subfamilies.Genetic analysis of single-minded 1 gene in early-onset severely obese children and adolescentsMPI-PHYLIP: parallelizing computationally intensive phylogenetic analysis routines for the analysis of large protein familiesMaking sense of cancer genomic data.Determinants, discriminants, conserved residues--a heuristic approach to detection of functional divergence in protein familiesSubtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.Exploiting structural classifications for function prediction: towards a domain grammar for protein function.Segtor: rapid annotation of genomic coordinates and single nucleotide variations using segment trees.The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations.Risk assessment of gastric cancer caused by Helicobacter pylori using CagA sequence markersVariants in GATA4 are a rare cause of familial and sporadic congenital diaphragmatic herniaSYK allelic loss and the role of Syk-regulated genes in breast cancer survival.Bayesian classification of residues associated with protein functional divergence: Arf and Arf-like GTPases.
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P2860
Determinants of protein function revealed by combinatorial entropy optimization
description
2007 թուականին հրատարակուած գիտական յօդուած
@hyw
2007 թվականին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
scientific article (publication date: 2007)
@en
vedecký článok (publikovaný 2007)
@sk
wetenschappelijk artikel (gepubliceerd in 2007)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована у 2007
@uk
مقالة علمية (نشرت عام 2007)
@ar
name
Determinants of protein function revealed by combinatorial entropy optimization
@ast
Determinants of protein function revealed by combinatorial entropy optimization
@en
Determinants of protein function revealed by combinatorial entropy optimization
@nl
type
label
Determinants of protein function revealed by combinatorial entropy optimization
@ast
Determinants of protein function revealed by combinatorial entropy optimization
@en
Determinants of protein function revealed by combinatorial entropy optimization
@nl
prefLabel
Determinants of protein function revealed by combinatorial entropy optimization
@ast
Determinants of protein function revealed by combinatorial entropy optimization
@en
Determinants of protein function revealed by combinatorial entropy optimization
@nl
P2860
P3181
P1433
P1476
Determinants of protein function revealed by combinatorial entropy optimization
@en
P2093
Boris Reva
P2860
P2888
P3181
P356
10.1186/GB-2007-8-11-R232
P407
P577
2007-01-01T00:00:00Z