The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress
about
The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and diseaseRibosomopathies: how a common root can cause a tree of pathologiesTargeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human diseasep53- and ERK7-dependent ribosome surveillance response regulates Drosophila insulin-like peptide secretionStructure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activationRole of ribosomal protein mutations in tumor development (Review)Transcription by RNA polymerase III: insights into mechanism and regulationRegulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New TricksYeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAsNSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translationNucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 proteinPICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathwayPICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway.Molecular characterization of 5S ribosomal RNA genes and transcripts in the protozoan parasite Leishmania major.Nucleolar stress with and without p53.Cellular differences in protein synthesis regulate tissue homeostasis.Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stressDysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia.Chaperoning 5S RNA assembly.Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated MicrocephalyThe RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression.Transcriptome Profiling Identifies Ribosome Biogenesis as a Target of Alcohol Teratogenicity and Vulnerability during Early Embryogenesis.A liaison between mTOR signaling, ribosome biogenesis and cancerProfiling of 2'-O-Me in human rRNA reveals a subset of fractionally modified positions and provides evidence for ribosome heterogeneity.Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesisHuman AATF/Che-1 forms a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis.The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis.Back to bases: how a nucleotide biosynthetic enzyme controls p53 activation.Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations.p53 and ribosome biogenesis stress: the essentials.The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA.Role of the nucleus in apoptosis: signaling and execution.BMH-21 inhibits viability and induces apoptosis by p53-dependent nucleolar stress responses in SKOV3 ovarian cancer cellsGradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A.Probing the mechanisms underlying human diseases in making ribosomes.mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels.Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress.RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance.
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The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress
description
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
@ast
im Oktober 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2013/10/17)
@nl
наукова стаття, опублікована в жовтні 2013
@uk
مقالة علمية (نشرت في 17-10-2013)
@ar
name
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress
@ast
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress
@en
type
label
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress
@ast
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress
@en
prefLabel
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress
@ast
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress
@en
P2860
P50
P921
P3181
P1433
P1476
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress
@en
P2093
Katherine E Sloan
P2860
P304
P3181
P356
10.1016/J.CELREP.2013.08.049
P577
2013-10-17T00:00:00Z