An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases
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Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoaAdvances in translational bioinformatics: computational approaches for the hunting of disease genesNetwork of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genesDefining the role of essential genes in human diseaseCellular hyperproliferation and cancer as evolutionary variablesA study in balance: how microbiomes are changing the shape of environmental healthPhylostratigraphic profiles in zebrafish uncover chordate origins of the vertebrate brain.Evolutionary profiling reveals the heterogeneous origins of classes of human disease genes: implications for modeling disease genetics in animalsHow old is my gene?On the origins of Mendelian disease genes in man: the impact of gene duplicationAnimals in a bacterial world, a new imperative for the life sciencesPhylostratigraphic profiles reveal a deep evolutionary history of the vertebrate head sensory systemsUnderstanding complex host-microbe interactions in HydraPhylostratigraphic Bias Creates Spurious Patterns of Genome EvolutionIntegrating Diverse Types of Genomic Data to Identify Genes that Underlie Adverse Pregnancy PhenotypesFocusHeuristics - expression-data-driven network optimization and disease gene predictionNo Evidence for Phylostratigraphic Bias Impacting Inferences on Patterns of Gene Emergence and Evolution.Similarly strong purifying selection acts on human disease genes of all evolutionary ages.Body-hypomethylated human genes harbor extensive intragenic transcriptional activity and are prone to cancer-associated dysregulationHeterogeneous molecular processes among the causes of how sequence similarity scores can fail to recapitulate phylogeny.The interplay between evolution, regulation and tissue specificity in the Human Hereditary Diseasome.Modification of gene duplicability during the evolution of protein interaction networkEvidence for the additions of clustered interacting nodes during the evolution of protein interaction networks from network motifs.Protein coalitions in a core mammalian biochemical network linked by rapidly evolving proteins.Ortho2ExpressMatrix--a web server that interprets cross-species gene expression data by gene family informationHuman functional genetic studies are biased against the medically most relevant primate-specific genes.ProteinHistorian: tools for the comparative analysis of eukaryote protein origin.Phylogenetic patterns of emergence of new genes support a model of frequent de novo evolution.Broker genes in human disease.Human monogenic disease genes have frequently functionally redundant paralogs.Relaxed purifying selection and possibly high rate of adaptation in primate lineage-specific genesGenome patterns of selection and introgression of haplotypes in natural populations of the house mouse (Mus musculus).Friends with social benefits: host-microbe interactions as a driver of brain evolution and development?NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings.Positron emission tomography and functional characterization of a complete PBR/TSPO knockout.Genes with a large intronic burden show greater evolutionary conservation on the protein levelSNP characteristics predict replication success in association studies.New genes drive the evolution of gene interaction networks in the human and mouse genomesEvolutionary hallmarks of the human proteome: chasing the age and coregulation of protein-coding genes.Exploring the potential relevance of human-specific genes to complex disease.
P2860
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P2860
An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases
@ast
An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases
@en
type
label
An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases
@ast
An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases
@en
prefLabel
An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases
@ast
An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases
@en
P2860
P3181
P356
P1476
An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases
@en
P2093
T. Domazet-Loso
P2860
P304
P3181
P356
10.1093/MOLBEV/MSN214
P577
2008-08-05T00:00:00Z