Metal ion catalysis in the Tetrahymena ribozyme reaction
about
A general two-metal-ion mechanism for catalytic RNADefining the chemical groups essential for Tetrahymena group I intron function by nucleotide analog interference mappingBiological phosphoryl-transfer reactions: understanding mechanism and catalysisPolymerase structures and function: variations on a theme?Functional identification of catalytic metal ion binding sites within RNA.On the origin of life in the Zinc world. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on EarthSolution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intronA relaxed active site after exon ligation by the group I intronA metal switch for controlling the activity of molecular motor proteinsNMR Structures and Dynamics in a Prohead RNA Loop that Binds Metal IonsThe first step of aminoacylation at the atomic level in histidyl-tRNA synthetaseChloroplast ribonuclease P does not utilize the ribozyme-type pre-tRNA cleavage mechanismCrystal structure of a phage Twort group I ribozyme-product complexThree metal ions at the active site of the Tetrahymena group I ribozymeRecent advances in the elucidation of the mechanisms of action of ribozymesMetal ion catalysis during group II intron self-splicing: parallels with the spliceosomeCombining a Clostridial enzyme exhibiting unusual active site plasticity with a remarkably facile sigmatropic rearrangement: rapid, stereocontrolled entry into densely functionalized fluorinated phosphonates for chemical biologyHow a chemist looks at RNA.Two major tertiary folding transitions of the Tetrahymena catalytic RNA.A second catalytic metal ion in group I ribozyme.Group I introns: new molecular mechanisms for mRNA repair.Salt-dependent folding energy landscape of RNA three-way junction.A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme.Rag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination.Crystal structure of a self-splicing group I intron with both exons.Ribozyme cleavage of a 2,5-phosphodiester linkage: mechanism and a restricted divalent metal-ion requirement.Thiophilic metal ion rescue of phosphorothioate interference within the Tetrahymena ribozyme P4-P6 domain.Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme.Evidence for an RNA-based catalytic mechanism in eukaryotic nuclear ribonuclease P.An unconventional origin of metal-ion rescue and inhibition in the Tetrahymena group I ribozyme reaction.Dissection of a metal-ion-mediated conformational change in Tetrahymena ribozyme catalysisSpecific phosphorothioate substitutions probe the active site of Bacillus subtilis ribonuclease P.Use of binding energy by an RNA enzyme for catalysis by positioning and substrate destabilization.Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophagesRecognition and cleavage of DNA by type-II restriction endonucleases.Metal binding by the D,DX35E motif of human immunodeficiency virus type 1 integrase: selective rescue of Cys substitutions by Mn2+ in vitroA minor groove RNA triple helix within the catalytic core of a group I intron.Selection of the best target site for ribozyme-mediated cleavage within a fusion gene for adenovirus E1A-associated 300 kDa protein (p300) and luciferase.Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNAA general and efficient approach for the construction of RNA oligonucleotides containing a 5'-phosphorothiolate linkage.
P2860
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P2860
Metal ion catalysis in the Tetrahymena ribozyme reaction
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Metal ion catalysis in the Tetrahymena ribozyme reaction
@ast
Metal ion catalysis in the Tetrahymena ribozyme reaction
@en
type
label
Metal ion catalysis in the Tetrahymena ribozyme reaction
@ast
Metal ion catalysis in the Tetrahymena ribozyme reaction
@en
prefLabel
Metal ion catalysis in the Tetrahymena ribozyme reaction
@ast
Metal ion catalysis in the Tetrahymena ribozyme reaction
@en
P356
P1433
P1476
Metal ion catalysis in the Tetrahymena ribozyme reaction
@en
P2093
Joseph A. Piccirilli
Joseph S. Vyle
P2888
P356
10.1038/361085A0
P407
P577
1993-01-07T00:00:00Z
P5875
P6179
1023604012