Elf5 inhibits the epithelial–mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2 - Test2 - elhamkhani - TriplyDB

Elf5 inhibits the epithelial–mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2

Elf5 inhibits the epithelial–mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2

http://www.wikidata.org/entity/Q29042375

about

Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer Targeting Breast Cancer Metastasis Crosstalk of the Insulin-Like Growth Factor Receptor with the Wnt Signaling Pathway in Breast Cancer Transcriptional control of cancer metastasis Mammary stem cells and the differentiation hierarchy: current status and perspectives Regulation of mesenchymal phenotype by MicroRNAs in cancer ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells.Distinctive properties of metastasis-initiating cells Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor ELF5 isoform expression is tissue-specific and significantly altered in cancer.Prolactin cooperates with loss of p53 to promote claudin-low mammary carcinomas CPEB1 promotes differentiation and suppresses EMT in mammary epithelial cells Minireview: prolactin regulation of adult stem cells Foxa1 is essential for mammary duct formation.Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells.Ovol proteins: guardians against EMT during epithelial differentiation Concise review: breast cancer stem cells: regulatory networks, stem cell niches, and disease relevance The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin.The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer.Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland.A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia.ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling.Multilayer control of the EMT master regulators.p38 MAPK inhibits breast cancer metastasis through regulation of stromal expansion.The mammary cellular hierarchy and breast cancer.The ETS family of oncogenic transcription factors in solid tumours.Expression profiling of migrated and invaded breast cancer cells predicts early metastatic relapse and reveals Krüppel-like factor 9 as a potential suppressor of invasive growth in breast cancer.Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis.RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells.Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state PDGFRα and β play critical roles in mediating Foxq1-driven breast cancer stemness and chemoresistance.Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer.Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transition.Paracrine Met signaling triggers epithelial-mesenchymal transition in mammary luminal progenitors, affecting their fate Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis.MicroRNA-93 Promotes Epithelial-Mesenchymal Transition of Endometrial Carcinoma Cells Gene regulatory network underlying the immortalization of epithelial cells.TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma.

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P2860

Elf5 inhibits the epithelial–mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2

http://www.wikidata.org/entity/Q29042375

description

2012 nî lūn-bûn

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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Elf5 inhibits the epithelial–m ...... criptionally repressing Snail2

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Elf5 inhibits the epithelial–m ...... criptionally repressing Snail2

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type

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Elf5 inhibits the epithelial–m ...... criptionally repressing Snail2

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Elf5 inhibits the epithelial–m ...... criptionally repressing Snail2

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Elf5 inhibits the epithelial–m ...... criptionally repressing Snail2

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Elf5 inhibits the epithelial–m ...... criptionally repressing Snail2

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Nature Cell Biology

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Elf5 inhibits the epithelial–m ...... criptionally repressing Snail2

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Bruce G. Haffty

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Dino Amadori

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Julie Hwang

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Kirsten Smalley

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Mario Andres Blanco

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Qifeng Yang

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Rose-Anne Romano

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Rumela Chakrabarti

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Satrajit Sinha

http://www.w3.org/2001/XMLSchema#string

Song Liu

http://www.w3.org/2001/XMLSchema#string

P2860

A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines

A new member of the ETS family fused to EWS in Ewing tumors

Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

The epithelial-mesenchymal transition generates cells with properties of stem cells

The epithelial-mesenchymal transition: new insights in signaling, development, and disease

Epithelial-mesenchymal transitions in tumour progression

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10.1038/NCB2607

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11

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14

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Laura Mercatali

Martin Lukačišin

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2012-10-21T00:00:00Z

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232533315

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1018595871

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23086238

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3500637

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