Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
about
The structural biology of Toll-like receptorsRecognition of lipopolysaccharide pattern by TLR4 complexesProtease signalling: the cutting edgeIntracellular nucleic acid sensors and autoimmunityRNA mediated Toll-like receptor stimulation in health and diseaseThe effects of TLR activation on T-cell development and differentiationNucleic acids and endosomal pattern recognition: how to tell friend from foe?TLR7/9 versus TLR3/MDA5 signaling during virus infections and diabetesAsparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activationRAGE is a nucleic acid receptor that promotes inflammatory responses to DNAStructural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stageStructural Basis for the Immunomodulatory Function of Cysteine Protease Inhibitor from Human Roundworm Ascaris lumbricoidesStructural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligandsStructural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9The role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsInnate immune pattern recognition: a cell biological perspectiveGuanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cellsDiscrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expressionNucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.Pathogen recognition by the innate immune systemDectin-1 Controls TLR9 Trafficking to Phagosomes Containing β-1,3 GlucanCytokines regulate cysteine cathepsins during TLR responses.TLR9 is actively recruited to Aspergillus fumigatus phagosomes and requires the N-terminal proteolytic cleavage domain for proper intracellular trafficking.The gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus 68 modulate the Toll-like receptor-induced proinflammatory cytokine response.Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3.Drosophila glycoprotein 93 Is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins.Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexesTRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5Carbohydrate oxidation acidifies endosomes, regulating antigen processing and TLR9 signaling.Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cellsUNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling.Plasmacytoid dendritic cells in multiple sclerosis: chemokine and chemokine receptor modulation by interferon-beta.Direct measurement of the interaction force between immunostimulatory CpG-DNA and TLR9 fusion protein.Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.Phospholipid scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.Dengue virus infection of the Aedes aegypti salivary gland and chemosensory apparatus induces genes that modulate infection and blood-feeding behaviorSecretion of the human Toll-like receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by Unc93b1.Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperoneTLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis.CD14 is a coreceptor of Toll-like receptors 7 and 9.
P2860
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P2860
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Proteolytic cleavage in an end ...... vation of Toll-like receptor 9
@ast
Proteolytic cleavage in an end ...... vation of Toll-like receptor 9
@en
type
label
Proteolytic cleavage in an end ...... vation of Toll-like receptor 9
@ast
Proteolytic cleavage in an end ...... vation of Toll-like receptor 9
@en
prefLabel
Proteolytic cleavage in an end ...... vation of Toll-like receptor 9
@ast
Proteolytic cleavage in an end ...... vation of Toll-like receptor 9
@en
P2093
P2860
P921
P3181
P356
P1433
P1476
Proteolytic cleavage in an end ...... vation of Toll-like receptor 9
@en
P2093
Boyoun Park
Clarissa C Lee
Eric Spooner
Hidde L Ploegh
P2860
P304
P3181
P356
10.1038/NI.1669
P407
P577
2008-10-19T00:00:00Z