Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells - Test2 - elhamkhani - TriplyDB

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

http://www.wikidata.org/entity/Q29614268

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The notch ligand JAGGED1 as a target for anti-tumor therapy Common molecular pathways involved in human CD133+/CD34+ progenitor cell expansion and cancer Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease Mammalian Krüppel-like factors in health and diseases Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear Treatment dilemmas of cetuximab combined with chemotherapy for metastatic colorectal cancer Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer Stem Cells in the Intestine: Possible Roles in Pathogenesis of Irritable Bowel Syndrome Gastrointestinal stem cells in health and disease: from flies to humans Targeting Notch to overcome radiation resistance Targeting cancer stem cells by using the nanoparticles Alzheimer's therapeutics: translation of preclinical science to clinical drug development Lineage selection and plasticity in the intestinal crypt Maintaining tissue homeostasis: dynamic control of somatic stem cell activity Non-canonical Notch signaling: emerging role and mechanism Targeting the Notch signaling pathway in cancer therapeutics Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins The intestinal epithelium tuft cells: specification and function Microenvironmental control of stem cell fate in intestinal homeostasis and disease Notch signaling in prostate cancer: a moving target Targeting γ-secretase in breast cancer Molecular mechanisms of diabetic kidney disease From fly wings to targeted cancer therapies: a centennial for notch signaling Defining hierarchies of stemness in the intestine: evidence from biomarkers and regulatory pathways Epigenetic silencing of Notch signaling in gastrointestinal cancers Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction Modelling the spatio-temporal cell dynamics reveals novel insights on cell differentiation and proliferation in the small intestinal crypt The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling The Integrated Role of Wnt/β-Catenin, N-Glycosylation, and E-Cadherin-Mediated Adhesion in Network Dynamics The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids.Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis.A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells Intestinal activation of Notch signaling induces rapid onset hepatic steatosis and insulin resistance Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo.A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer.KRAS-driven lung adenocarcinoma: combined DDR1/Notch inhibition as an effective therapy

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P2860

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

http://www.wikidata.org/entity/Q29614268

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2005 nî lūn-bûn

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2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2005 թվականի հունիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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Notch/gamma-secretase inhibiti ...... and adenomas into goblet cells

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Notch/gamma-secretase inhibiti ...... and adenomas into goblet cells

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Notch/gamma-secretase inhibiti ...... and adenomas into goblet cells

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Notch/gamma-secretase inhibiti ...... and adenomas into goblet cells

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Notch/gamma-secretase inhibiti ...... and adenomas into goblet cells

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Notch/gamma-secretase inhibiti ...... and adenomas into goblet cells

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Begthel H

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Clevers H

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Cozijnsen M

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van Gijn ME

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10.1038/NATURE03659

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