An unnatural base pair system for efficient PCR amplification and functionalization of DNA molecules
about
Highly specific unnatural base pair systems as a third base pair for PCR amplificationEfficient and sequence-independent replication of DNA containing a third base pair establishes a functional six-letter genetic alphabetGeneration of high-affinity DNA aptamers using an expanded genetic alphabetAmplification, mutation, and sequencing of a six-letter synthetic genetic systemSolution Structure, Mechanism of Replication, and Optimization of an Unnatural Base PairRecent advances in synthetic biosafetySystematic exploration of a class of hydrophobic unnatural base pairs yields multiple new candidates for the expansion of the genetic alphabetMajor groove derivatization of an unnatural base pair.In vitro selection with artificial expanded genetic information systemsExpanded genetic alphabets in the polymerase chain reaction.DNA-catalyzed reductive aminationMeasurement and theory of hydrogen bonding contribution to isosteric DNA base pairs.The Toolbox for Modified Aptamers.PCR amplification and transcription for site-specific labeling of large RNA molecules by a two-unnatural-base-pair systemUnnatural base pair systems toward the expansion of the genetic alphabet in the central dogmaBiological phosphorylation of an Unnatural Base Pair (UBP) using a Drosophila melanogaster deoxynucleoside kinase (DmdNK) mutant.The expanded genetic alphabet.Expanding the scope of replicable unnatural DNA: stepwise optimization of a predominantly hydrophobic base pair.Major groove substituents and polymerase recognition of a class of predominantly hydrophobic unnatural base pairs.The effects of unnatural base pairs and mispairs on DNA duplex stability and solvation.Non-natural nucleic acids for synthetic biology.Site-specifically arraying small molecules or proteins on DNA using an expanded genetic alphabetSite-specific labeling of DNA and RNA using an efficiently replicated and transcribed class of unnatural base pairs.Towards XNA nanotechnology: new materials from synthetic genetic polymersPost-ExSELEX stabilization of an unnatural-base DNA aptamer targeting VEGF165 toward pharmaceutical applications.2-Methoxypyridine as Thymidine Mimic in Watson-Crick Base Pairs of DNA and PNA: Synthesis, Thermal Stability and NMR Structural Studies.Natural-like replication of an unnatural base pair for the expansion of the genetic alphabet and biotechnology applications.How do hydrophobic nucleobases differ from natural DNA nucleobases? Comparison of structural features and duplex properties from QM calculations and MD simulations.Expansion of the DNA Alphabet beyond Natural DNA Recognition.Cellular processing and destinies of artificial DNA nanostructures.Cycloadditions for Studying Nucleic Acids.Alternative Watson-Crick Synthetic Genetic Systems.Site-specific labeling of RNA by combining genetic alphabet expansion transcription and copper-free click chemistry.PCR with an expanded genetic alphabet.Synthetic polymers and their potential as genetic materials.Evolving Aptamers with Unnatural Base Pairs.Structure and Biophysics for a Six Letter DNA Alphabet that Includes Imidazo[1,2-a]-1,3,5-triazine-2(8H)-4(3H)-dione (X) and 2,4-Diaminopyrimidine (K).Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair.Helix instability and self-pairing prevent unnatural base pairs from expanding the genetic alphabet.Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase.
P2860
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P2860
An unnatural base pair system for efficient PCR amplification and functionalization of DNA molecules
description
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artikull shkencor
@sq
artículu científicu espublizáu en 2008
@ast
im Dezember 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 10 December 2008)
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 2008
@uk
مقالة علمية (نشرت في 10-12-2008)
@ar
name
An unnatural base pair system ...... tionalization of DNA molecules
@ast
An unnatural base pair system ...... tionalization of DNA molecules
@en
type
label
An unnatural base pair system ...... tionalization of DNA molecules
@ast
An unnatural base pair system ...... tionalization of DNA molecules
@en
prefLabel
An unnatural base pair system ...... tionalization of DNA molecules
@ast
An unnatural base pair system ...... tionalization of DNA molecules
@en
P2093
P2860
P3181
P356
P1476
An unnatural base pair system ...... tionalization of DNA molecules
@en
P2093
Ichiro Hirao
Michiko Kimoto
Tsuneo Mitsui
P2860
P304
P3181
P356
10.1093/NAR/GKN956
P407
P577
2008-12-10T00:00:00Z