Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice - Test2 - elhamkhani - TriplyDB

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

http://www.wikidata.org/entity/Q30080001

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pH sensing and regulation in cancer Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study Understanding the Warburg effect: the metabolic requirements of cell proliferation HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells Links between metabolism and cancer HIF-1: upstream and downstream of cancer metabolism Targeting Cancer Metabolism - Revisiting the Warburg Effects Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction Pathophysiological Basis for the Formation of the Tumor Microenvironment Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance Cancer Metabolism: A Modeling Perspective Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics Hypoxia and metabolic adaptation of cancer cells Dysregulated metabolism contributes to oncogenesis Metabolic reprogramming: the emerging concept and associated therapeutic strategies Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies Molecular pathways: trafficking of metabolic resources in the tumor microenvironment Adipose tissue and adipocytes support tumorigenesis and metastasis Adipocytes: impact on tumor growth and potential sites for therapeutic intervention Is cancer a metabolic disease?Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments Pathways and therapeutic targets in melanoma Alternative fuels for cancer cells Role of oxidative stress and the microenvironment in breast cancer development and progression Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy Immunometabolism in Tuberculosis Heterogeneity of glycolysis in cancers and therapeutic opportunities.A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis.The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters The Warburg effect: 80 years on Reexamining cancer metabolism: Lactate production for carcinogenesis could be the purpose and explanation of the Warburg effect The ever-expanding role of HIF in tumour and stromal biology ROS homeostasis and metabolism: a critical liaison for cancer therapy Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

http://www.wikidata.org/entity/Q30080001

description

2008 nî lūn-bûn

@nan

2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

@zh-hk

2008年論文

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2008年論文

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2008年论文

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name

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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Journal of Clinical Investigation

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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

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P2093

De Saedeleer CJ

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Dewhirst MW

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Diepart C

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Feron O

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Gallez B

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Jordan BF

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Kelley MJ

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Kennedy KM

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Rabbani ZN

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Schroeder T

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P2860

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

Exploiting tumour hypoxia in cancer treatment

Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex

Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.

Oncogenic alterations of metabolism.

Causes and consequences of tumour acidity and implications for treatment.

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3930-42

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scholarly article

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273031

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10.1172/JCI36843

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12

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118

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2008-12-01T00:00:00Z

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23497515

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19033663

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2582933

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