Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activitiesSynthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's diseaseAnalogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): development of ligands with optimized lipophilicity and binding affinityBioactive heterocycles containing endocyclic N-hydroxy groupsSynthetic strategy and antiviral evaluation of diamide containing heterocycles targeting dengue and yellow fever virusSynthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinasesDesign of novel aminopyrrolidine factor Xa inhibitors from a screening hitMapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitorsIdentification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthaseSynthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central coreThe identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discoveryStructure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs)7-Substituted pterins provide a new direction for ricin A chain inhibitorsSecond-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acidNew 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluationFragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinaseDesign of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrasesSynthesis and biological evaluation of novel (-)-Cercosporamide derivatives as potent selective PPARγ modulatorsThe binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessmentDevelopment of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoesDiscovery and characterization of novel allosteric FAK inhibitorsImidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysisDesign, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteasesSynthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurFLead identification of novel and selective TYK2 inhibitorsSynthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1ADiscovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitorsMultiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factorLuciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitorsCarbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoformsIdentification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS)Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactionsDiscovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell modelsDiscovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitorDiscovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structureStructure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrasesNovel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl)methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1
P1433
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P1433
description
begutachtete wissenschaftliche Fachzeitschrift
@de
peer-reviewed scientific journal
@en
revista científica
@es
rivista scientifica
@it
vědecký časopis
@cs
wetenschappelijk tijdschrift van Elsevier
@nl
рецензований науковий журнал
@uk
वैज्ञानिक पत्रिका
@hi
英语期刊
@zh
name
European Journal of Medicinal Chemistry
@ast
European Journal of Medicinal Chemistry
@da
European Journal of Medicinal Chemistry
@de
European Journal of Medicinal Chemistry
@en
European Journal of Medicinal Chemistry
@es
European Journal of Medicinal Chemistry
@fi
European Journal of Medicinal Chemistry
@fr
European Journal of Medicinal Chemistry
@it
European Journal of Medicinal Chemistry
@nb
European Journal of Medicinal Chemistry
@nl
type
label
European Journal of Medicinal Chemistry
@ast
European Journal of Medicinal Chemistry
@da
European Journal of Medicinal Chemistry
@de
European Journal of Medicinal Chemistry
@en
European Journal of Medicinal Chemistry
@es
European Journal of Medicinal Chemistry
@fi
European Journal of Medicinal Chemistry
@fr
European Journal of Medicinal Chemistry
@it
European Journal of Medicinal Chemistry
@nb
European Journal of Medicinal Chemistry
@nl
altLabel
Eur. J. Med. Chem
@pl
prefLabel
European Journal of Medicinal Chemistry
@ast
European Journal of Medicinal Chemistry
@da
European Journal of Medicinal Chemistry
@de
European Journal of Medicinal Chemistry
@en
European Journal of Medicinal Chemistry
@es
European Journal of Medicinal Chemistry
@fi
European Journal of Medicinal Chemistry
@fr
European Journal of Medicinal Chemistry
@it
European Journal of Medicinal Chemistry
@nb
European Journal of Medicinal Chemistry
@nl
P236
P6981
P214
P243
P244
P3181
P4616
P1058
P1156
P1159
P1160
Eur. J. Med. Chem.
P123
P1250
P1277
P1476
European Journal of Medicinal Chemistry
@en