about
Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of ParkinsonismBiochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimersDifferential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathwaysInsight into the mode of action of the LRRK2 Y1699C pathogenic mutantA direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylationFK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53TThe Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sitesIdentification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycleThe Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylationUnbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson diseaseP2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathyA lipid switch unlocks Parkinson's disease-associated ATP13A2Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brainEndonuclease G mediates α-synuclein cytotoxicity during Parkinson's diseaseRegulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin.Automated quantitative gait analysis in animal models of movement disorders.Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis.Comparison of lentiviral vector titration methods.Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice.Seeing genes at work in the living brain with non-invasive molecular imaging.Immunohistochemical detection of transgene expression in the brain using small epitope tags.Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.Construction and evaluation of quantitative small-animal PET probabilistic atlases for [¹⁸F]FDG and [¹⁸F]FECT functional mapping of the mouse brainNigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkBLong-Term Fate Mapping Using Conditional Lentiviral Vectors Reveals a Continuous Contribution of Radial Glia-Like Cells to Adult Hippocampal Neurogenesis in Mice.Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortexConcise review: therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis.Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networksMitophagy-driven mitochondrial rejuvenation regulates stem cell fateIn vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants.Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate.Unraveling the role of peptidyl-prolyl isomerases in neurodegeneration.Kinases as targets for Parkinson's disease: from genetics to therapy.Phosphorylation of LRRK2: from kinase to substrate.The remarkable conformational plasticity of alpha-synuclein: blessing or curse?
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Veerle Baekelandt
@ast
Veerle Baekelandt
@en
Veerle Baekelandt
@es
Veerle Baekelandt
@nl
Veerle Baekelandt
@sl
type
label
Veerle Baekelandt
@ast
Veerle Baekelandt
@en
Veerle Baekelandt
@es
Veerle Baekelandt
@nl
Veerle Baekelandt
@sl
prefLabel
Veerle Baekelandt
@ast
Veerle Baekelandt
@en
Veerle Baekelandt
@es
Veerle Baekelandt
@nl
Veerle Baekelandt
@sl
P106
P21
P31
P569
2000-01-01T00:00:00Z