ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1. - Test2 - elhamkhani - TriplyDB

ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.

ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.

http://www.wikidata.org/entity/Q30155948

about

Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1 A novel BCR-ABL1 fusion gene identified by next-generation sequencing in chronic myeloid leukemia.Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling.The RAB5-GEF function of RIN1 regulates multiple steps during Listeria monocytogenes infection Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR.Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies.RIN1 exhibits oncogenic property to suppress apoptosis and its aberrant accumulation associates with poor prognosis in melanoma.Changing the subcellular location of the oncoprotein Bcr-Abl using rationally designed capture motifs

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P2860

ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.

http://www.wikidata.org/entity/Q30155948

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

ABL fusion oncogene transforma ...... y the cellular regulator RIN1.

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ABL fusion oncogene transforma ...... y the cellular regulator RIN1.

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type

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ABL fusion oncogene transforma ...... y the cellular regulator RIN1.

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ABL fusion oncogene transforma ...... y the cellular regulator RIN1.

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prefLabel

ABL fusion oncogene transforma ...... y the cellular regulator RIN1.

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ABL fusion oncogene transforma ...... y the cellular regulator RIN1.

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ABL fusion oncogene transforma ...... y the cellular regulator RIN1.

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D Cheng

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J Colicelli

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J McLaughlin

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M Müschen

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M Thai

http://www.w3.org/2001/XMLSchema#string

O N Witte

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P Y Ting

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P2860

The RAS effector RIN1 modulates the formation of aversive memories

RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration

AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance

A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1

Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

Structural basis for the autoinhibition of c-Abl tyrosine kinase

Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression

Two distinct phosphorylation pathways have additive effects on Abl family kinase activation

Regulated expression of the Ras effector Rin1 in forebrain neurons

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290-300

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10.1038/LEU.2010.268

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2

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25

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1028113322

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21102429

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3049868

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