Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.
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Kinetic and spectroscopic studies of N694C lipoxygenase: a probe of the substrate activation mechanism of a nonheme ferric enzymeDynamically achieved active site precision in enzyme catalysisAt the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?Evidence for substrate preorganization in the peptidylglycine α-amidating monooxygenase reaction describing the contribution of ground state structure to hydrogen tunnelingPerspective: Defining and quantifying the role of dynamics in enzyme catalysisAn integrated model for enzyme catalysis emerges from studies of hydrogen tunneling.Hydrogen tunneling links protein dynamics to enzyme catalysisUpdate 1 of: Tunneling and dynamics in enzymatic hydride transfer.Elusive transition state of alcohol dehydrogenase unveiled.Characterizing the dynamics of functionally relevant complexes of formate dehydrogenase.Proton-coupled electron transfer in biology: results from synergistic studies in natural and model systems.Chemistry of personalized solar energy.Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactorsCoordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase.Isotope effects as probes for enzyme catalyzed hydrogen-transfer reactions.Kinetic effects of increased proton transfer distance on proton-coupled oxidations of phenol-amines.Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol.Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidationsActive site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures.Competition H(D) kinetic isotope effects in the autoxidation of hydrocarbonsHeavy-enzyme kinetic isotope effects on proton transfer in alanine racemase.Hydrogen atom transfer reactions of a ruthenium imidazole complex: hydrogen tunneling and the applicability of the Marcus cross relation.Computation of kinetic isotope effects for enzymatic reactions.Experimental evidence for hydrogen tunneling when the isotopic arrhenius prefactor (A(H)/A(D)) is unity.Nitroxyl radical plus hydroxylamine pseudo self-exchange reactions: tunneling in hydrogen atom transfer.Kinetic isotope effects as a probe of hydrogen transfers to and from common enzymatic cofactorsOscillatory Enzyme Dynamics Revealed by Two-Dimensional Infrared Spectroscopy.Enzymatic methyl transfer: role of an active site residue in generating active site compaction that correlates with catalytic efficiency.Arrhenius curves of hydrogen transfers: tunnel effects, isotope effects and effects of pre-equilibria.Expression of fusion proteins of Aspergillus terreus reveals a novel allene oxide synthase.Stereospecific multiple isotopic labeling of benzyl alcohol.Introduction. Biomolecular simulation.Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects.A critical test of the "tunneling and coupled motion" concept in enzymatic alcohol oxidation.Investigating inner-sphere reorganization via secondary kinetic isotope effects in the C-H cleavage reaction catalyzed by soybean lipoxygenase: tunneling in the substrate backbone as well as the transferred hydrogen.Synthesis of Site-Specifically 13C Labeled Linoleic Acids.Exploring the molecular origins of protein dynamics in the active site of human carbonic anhydrase IIKinetic isotope effects on aromatic and benzylic hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase as probes of chemical mechanism and reactivity.Evolution of the concept of conformational dynamics of enzyme functions over half of a century: A personal view.
P2860
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P2860
Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.
@ast
Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.
@en
type
label
Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.
@ast
Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.
@en
prefLabel
Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.
@ast
Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.
@en
P2860
P356
P1476
Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.
@en
P2093
Judith P Klinman
P2860
P304
P356
10.1098/RSTB.2006.1870
P407
P577
2006-08-01T00:00:00Z