Therapeutic considerations for Mdm2: not just a one trick pony - Test2 - elhamkhani - TriplyDB

Therapeutic considerations for Mdm2: not just a one trick pony

Therapeutic considerations for Mdm2: not just a one trick pony

http://www.wikidata.org/entity/Q30380490

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TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer.Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress.Structure- and ligand-based virtual screening identifies new scaffolds for inhibitors of the oncoprotein MDM2.

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Therapeutic considerations for Mdm2: not just a one trick pony

http://www.wikidata.org/entity/Q30380490

description

2008 nî lūn-bûn

@nan

2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Therapeutic considerations for Mdm2: not just a one trick pony

@ast

Therapeutic considerations for Mdm2: not just a one trick pony

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type

label

Therapeutic considerations for Mdm2: not just a one trick pony

@ast

Therapeutic considerations for Mdm2: not just a one trick pony

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prefLabel

Therapeutic considerations for Mdm2: not just a one trick pony

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Therapeutic considerations for Mdm2: not just a one trick pony

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17460441.3.11.1309

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Expert Opinion on Drug Discovery

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Therapeutic considerations for Mdm2: not just a one trick pony

@en

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Christopher N Batuello

http://www.w3.org/2001/XMLSchema#string

Jacob A Eitel

http://www.w3.org/2001/XMLSchema#string

Jason A Lehman

http://www.w3.org/2001/XMLSchema#string

Lindsey D Mayo

http://www.w3.org/2001/XMLSchema#string

P2860

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

HDM2-binding partners: interaction with translation elongation factor EF1alpha.

The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Mdm2 promotes the rapid degradation of p53

Nucleophosmin is essential for ribosomal protein L5 nuclear export

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1309-1321

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scholarly article

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10.1517/17460441.3.11.1309

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11

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3

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2008-11-01T00:00:00Z

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19738896

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2717507

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