Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets. - Test2 - elhamkhani - TriplyDB

Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

http://www.wikidata.org/entity/Q30418321

about

High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression Metabolomics applied to the pancreatic islet Histone deacetylases as targets for treatment of multiple diseases RBM4 promotes pancreas cell differentiation and insulin expression Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model.Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Insulin gene expression is regulated by DNA methylation The nuclear orphan receptor Nur77 is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.Mig6 haploinsufficiency protects mice against streptozotocin-induced diabetes Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II.Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell.Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress.Translational control of inducible nitric oxide synthase by p38 MAPK in islet β-cells Growth factor control of pancreatic islet regeneration and function Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.Mouse and human islets survive and function after coating by biosilicification Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.A novel extract of Gymnema sylvestre improves glucose tolerance in vivo and stimulates insulin secretion and synthesis in vitro.A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response.Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus.Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets.Regulation of insulin gene transcription by multiple histone acetyltransferases.Microassay for glucose-induced preproinsulin mRNA expression to assess islet functional potency for islet transplantation.Novel splice variant of mouse insulin2 mRNA: implications for insulin expression.Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.Featured Article: Beta cell specific pyruvate dehydrogenase alpha gene deletion results in a reduced islet number and β-cell mass postnatally.Interaction of HuDA and PABP at 5'UTR of mouse insulin2 regulates insulin biosynthesis.

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P2860

Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

http://www.wikidata.org/entity/Q30418321

description

2007 nî lūn-bûn

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2007 թուականի Մարտին հրատարակուած գիտական յօդուած

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2007 թվականի մարտին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

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Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

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Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

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Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

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Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

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Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

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Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.

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James C Garmey

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Kenneth L Brayman

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Raghavendra G Mirmira

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Robert Ketchum

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Shaoping Deng

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P2860

Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.

The unique cytoarchitecture of human pancreatic islets has implications for islet cell function

Splicing in action: assessing disease causing sequence changes

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

Histone acetylation and an epigenetic code

Regulation of insulin gene transcription

Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence

Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding.

Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.

The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantation.

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827-835

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10.2337/DB06-1440

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3

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56

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Carmella Evans-Molina

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6479983

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3705758

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