Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells
about
Emerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleGenomic instability in liver cells caused by an LPS-induced bystander-like effectNucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functionsNucleolin and nucleophosmin: nucleolar proteins with multiple functions in DNA repair.Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell linesIdentification of inhibitors of biological interactions involving intrinsically disordered proteins.Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor propertiesTranscriptional Up-Regulation of APE1/Ref-1 in Hepatic Tumor: Role in Hepatocytes Resistance to Oxidative Stress and Apoptosis.Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigenRegulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation.APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation.Prediction of survival prognosis of non-small cell lung cancer by APE1 through regulation of Epithelial-Mesenchymal Transition.Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.Human apurinic/apyrimidinic endonuclease 1.SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements.Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair.Battle against RNA oxidation: molecular mechanisms for reducing oxidized RNA to protect cells.BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management.Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.Crosstalk between the nucleolus and the DNA damage response.Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.MicroRNA-765 Enhances the Anti-Angiogenic Effect of CDDP via APE1 in Osteosarcoma.Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.Base excision DNA repair and cancer.Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin).CREBBP and p300 lysine acetyl transferases in the DNA damage response.Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin.Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori
P2860
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P2860
Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Nucleolar accumulation of APE1 ...... late its BER activity in cells
@ast
Nucleolar accumulation of APE1 ...... late its BER activity in cells
@en
type
label
Nucleolar accumulation of APE1 ...... late its BER activity in cells
@ast
Nucleolar accumulation of APE1 ...... late its BER activity in cells
@en
prefLabel
Nucleolar accumulation of APE1 ...... late its BER activity in cells
@ast
Nucleolar accumulation of APE1 ...... late its BER activity in cells
@en
P2093
P2860
P50
P356
P1476
Nucleolar accumulation of APE1 ...... late its BER activity in cells
@en
P2093
Daniela Marasco
Franco Quadrifoglio
Kishor K Bhakat
Mattia Poletto
Milena Romanello
P2860
P304
P356
10.1091/MBC.E12-04-0299
P50
P577
2012-08-23T00:00:00Z