Functional GI disorders: from animal models to drug development. - Test2 - elhamkhani - TriplyDB

Functional GI disorders: from animal models to drug development.

Functional GI disorders: from animal models to drug development.

http://www.wikidata.org/entity/Q30433078

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Towards a systems view of IBS Toll-like receptor mRNA expression is selectively increased in the colonic mucosa of two animal models relevant to irritable bowel syndrome Stress and visceral pain: from animal models to clinical therapies A combined nutrient and lactulose challenge test allows symptom-based clustering of patients with irritable bowel syndrome.Gastrointestinal transit measurements in mice with 99mTc-DTPA-labeled activated charcoal using NanoSPECT-CT.Citalopram provides little or no benefit in nondepressed patients with irritable bowel syndrome.Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome.Review article: new receptor targets for medical therapy in irritable bowel syndrome Gut feelings: the emerging biology of gut-brain communication.Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Methods to assess visceral hypersensitivity in irritable bowel syndrome.Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders.Protocol for a randomized controlled study of Iyengar yoga for youth with irritable bowel syndrome.Effects of the N-methyl-D-aspartate receptor on temporal summation of second pain (wind-up) in irritable bowel syndrome.Resistance to early-life stress in mice: effects of genetic background and stress duration.Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis.The severity of irritable bowel syndrome or the presence of fibromyalgia influencing the perception of visceral and somatic stimuli A cognitive-behavioral treatment for irritable bowel syndrome using interoceptive exposure to visceral sensations.Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities.Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study.Proximal colon distension induces Fos expression in oxytocin-, vasopressin-, CRF- and catecholamines-containing neurons in rat brain.Predictive validity of behavioural animal models for chronic pain Epidemiology of pediatric functional abdominal pain disorders: a meta-analysis.Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome Behavioral and molecular processing of visceral pain in the brain of mice: impact of colitis and psychological stress Interaction between P2X3 and oestrogen receptor (ER)α/ERβ in ATP-mediated calcium signalling in mice sensory neurones.New insights into visceral hypersensitivity--clinical implications in IBS Contingency Awareness Shapes Acquisition and Extinction of Emotional Responses in a Conditioning Model of Pain-Related Fear.Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis.Electroacupuncture alleviates stress-induced visceral hypersensitivity through an opioid system in rats Genome-wide DNA methylation profiling of peripheral blood mononuclear cells in irritable bowel syndrome.Development of a novel mouse constipation model Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1 Visceral analgesics: drugs with a great potential in functional disorders?Lower gastrointestinal functions.Challenges to the therapeutic pipeline for irritable bowel syndrome: end points and regulatory hurdles.Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation.The brain-gut axis in abdominal pain syndromes.Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome Maternal separation as a model of brain-gut axis dysfunction.Mechanisms underlying visceral hypersensitivity in irritable bowel syndrome.

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Functional GI disorders: from animal models to drug development.

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Tegaserod for the treatment of irritable bowel syndrome

Involvement of endogenous CCK and CCK1 receptors in colonic motor function

CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome

Spared nerve injury rats exhibit thermal hyperalgesia on an automated operant dynamic thermal escape task

Inflammatory and neuropathic pain animals exhibit distinct responses to innocuous thermal and motoric challenges.

Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils

Opinion: NK3 receptor antagonists: the next generation of antipsychotics?

Effects of octreotide on responses to colorectal distension in the rat

Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress.

Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome.

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